Montelukast and Prednisolone Interaction
Drug interaction information between Montelukast and Prednisolone.
Montelukast and Prednisolone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Montelukast and Prednisolone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
There is no evidence that these medicines affect each other's levels or performance in the body.
FDA Label Information
DRUG INTERACTIONS No dose adjustment is needed when montelukast sodium is co-administered with theophylline, prednisone, prednisolone, oral contraceptives, terfenadine, digoxin, warfarin, gemfibrozil, itraconazole, thyroid hormones, sedative hypnotics, non-steroidal anti-inflammatory agents, benzodiazepines, decongestants, and Cytochrome P450 (CYP) enzyme inducers [see Clinical Pharmacology (12.3)] .
Montelukast Also Interacts With
- Prednisone minor
- Warfarin minor
- Itraconazole minor
- Digoxin minor
- Theophylline minor
Prednisolone Also Interacts With
- Theophylline major
- Darunavir moderate
- Nirmatrelvir/Ritonavir moderate
- Carbamazepine minor
- Estradiol minor
Frequently Asked Questions
What SPL severity band is on file for Montelukast + Prednisolone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Prednisolone has 14 labeled pairs on file vs Montelukast's 8. In the minor band specifically: Montelukast has 8 (also Prednisone, Warfarin, Itraconazole, Digoxin); Prednisolone has 11 (also Carbamazepine, Estradiol, Ethinyl Estradiol, Ethinyl Estradiol).
What mechanism field is on file for Montelukast and Prednisolone?
There is no evidence that these medicines affect each other's levels or performance in the body.
Prednisolone carries more major-labeled pairs than Montelukast
SPL source-record counts only. This page's band is minor · classes on file: Montelukast (Leukotriene Receptor Antagonist); Prednisolone (Corticosteroid).
Prednisolone has 1 major-labeled pair vs Montelukast's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 8 minor · 8 total
- Other minor peers for Montelukast
- Prednisone
- Warfarin
- Itraconazole
- Digoxin
1 major · 2 moderate · 11 minor · 14 total
- Other minor peers for Prednisolone
- Carbamazepine
- Estradiol
- Ethinyl Estradiol
- Ethinyl Estradiol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.