Miglitol and Glyburide Interaction
Drug interaction information between Miglitol and Glyburide.
Miglitol and Glyburide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Miglitol and Glyburide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Miglitol can lower the amount of glyburide that enters your blood.
FDA Label Information
Drug Interactions Several studies investigated the possible interaction between miglitol and glyburide. In six healthy volunteers given a single dose of 5 mg glyburide on a background of 6 days treatment with miglitol (50 mg 3 times daily for 4 days followed by 100 mg 3 times daily for 2 days) or placebo, the mean C max and AUC values for glyburide were 17% and 25% lower, respectively, when glyburide was given with miglitol. In a study in diabetic patients in which the effects of adding miglitol 100 mg 3 times daily for 7 days or placebo to a background regimen of 3.5 mg glyburide daily...
Miglitol Also Interacts With
- Metformin minor
- Propranolol minor
- Warfarin minor
- Nifedipine minor
- Ranitidine minor
Glyburide Also Interacts With
- Fluvastatin moderate
- Colesevelam minor
- Eprosartan minor
- Etodolac minor
- Fluconazole minor
Frequently Asked Questions
What SPL severity band is on file for Miglitol + Glyburide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Glyburide has 9 labeled pairs on file vs Miglitol's 7. In the minor band specifically: Miglitol has 7 (also Metformin, Propranolol, Warfarin, Nifedipine); Glyburide has 8 (also Colesevelam, Eprosartan, Etodolac, Fluconazole).
What mechanism field is on file for Miglitol and Glyburide?
Miglitol can lower the amount of glyburide that enters your blood.
Glyburide's labeled portfolio outnumbers Miglitol
SPL source-record counts only. This page's band is minor · classes on file: Miglitol (Alpha-Glucosidase Inhibitor); Glyburide (Sulfonylurea).
0 major · 0 moderate · 7 minor · 7 total
- Other minor peers for Miglitol
- Metformin
- Propranolol
- Warfarin
- Nifedipine
0 major · 1 moderate · 8 minor · 9 total
- Other minor peers for Glyburide
- Colesevelam
- Eprosartan
- Etodolac
- Fluconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.