Glyburide and Eprosartan Interaction
Drug interaction information between Glyburide and Eprosartan.
Glyburide and Eprosartan have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Glyburide and Eprosartan. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Eprosartan does not change how glyburide works to control your blood sugar levels.
What To Do
It is safe to take these together, but continue to check your blood sugar levels as your doctor recommends.
FDA Label Information
Concomitant administration of eprosartan and glyburide in diabetic patients did not affect 24-hour plasma glucose profiles. Eprosartan has been shown to have no effect on the pharmacokinetics of digoxin and the pharmacodynamics of warfarin and glyburide.
Glyburide Also Interacts With
- Fluvastatin moderate
- Colesevelam minor
- Etodolac minor
- Fluconazole minor
- Miglitol minor
Eprosartan Also Interacts With
- Aliskiren major
- Hydrochlorothiazide minor
- Warfarin minor
- Nifedipine minor
- Ketoconazole minor
Frequently Asked Questions
Can I take Glyburide and Eprosartan together?
This is a minor interaction. It is safe to take these together, but continue to check your blood sugar levels as your doctor recommends.
How serious is the interaction between Glyburide and Eprosartan?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Glyburide and Eprosartan interact?
Eprosartan does not change how glyburide works to control your blood sugar levels.
Understanding the Glyburide and Eprosartan Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Glyburide belongs to the Sulfonylurea class and Eprosartan belongs to the Angiotensin II Receptor Blocker (ARB) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Eprosartan does not change how glyburide works to control your blood sugar levels. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Glyburide has 9 total documented interactions on file in this dataset, and Eprosartan has 9. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: It is safe to take these together, but continue to check your blood sugar levels as your doctor recommends. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Glyburide or Eprosartan based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.