Glyburide and Fluvastatin Interaction
Drug interaction information between Glyburide and Fluvastatin.
Glyburide and Fluvastatin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Glyburide and Fluvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluvastatin can increase the amount of glyburide in your system, which may cause your blood sugar to drop too low.
FDA Label Information
Caution should be used when prescribing with fluvastatin ( 5.1 , 7.3 , 7.4 ) Glyburide: Monitor blood glucose levels when fluvastatin dose is changed ( 7 ) Phenytoin: Monitor plasma phenytoin levels when fluvastatin treatment is initiated or when the dosage is changed ( 7 ) Warfarin and coumarin derivates: Monitor prothrombin times when fluvastatin coadministration is initiated, discontinued, or the dosage changed ( 7 ) 7.1 Cyclosporine Cyclosporine coadministration increases fluvastatin exposure. 7.6 Glyburide Concomitant administration of fluvastatin and glyburide increased glyburide...
Glyburide Also Interacts With
- Colesevelam minor
- Eprosartan minor
- Etodolac minor
- Fluconazole minor
- Miglitol minor
Fluvastatin Also Interacts With
- Clarithromycin major
- Cyclosporine moderate
- Gemfibrozil moderate
- Niacin moderate
- Phenytoin moderate
Frequently Asked Questions
What SPL severity band is on file for Glyburide + Fluvastatin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluvastatin has 12 labeled pairs on file vs Glyburide's 9. In the moderate band specifically: Glyburide has 1; Fluvastatin has 6 (also Cyclosporine, Gemfibrozil, Niacin, Phenytoin).
What mechanism field is on file for Glyburide and Fluvastatin?
Fluvastatin can increase the amount of glyburide in your system, which may cause your blood sugar to drop too low.
Fluvastatin carries more major-labeled pairs than Glyburide
SPL source-record counts only. This page's band is moderate · classes on file: Glyburide (Sulfonylurea); Fluvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Fluvastatin has 1 major-labeled pair vs Glyburide's 0. This page itself is in the moderate band, not the major band.
0 major · 1 moderate · 8 minor · 9 total
Glyburide has no other moderate-band peer in this dataset besides Fluvastatin.
1 major · 6 moderate · 5 minor · 12 total
- Other moderate peers for Fluvastatin
- Cyclosporine
- Gemfibrozil
- Niacin
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.