Glyburide and Fluconazole Interaction
Drug interaction information between Glyburide and Fluconazole.
Glyburide and Fluconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Glyburide and Fluconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluconazole slows down how the body breaks down glyburide, which causes the diabetes medicine to stay in the blood longer. This can lead to blood sugar levels dropping too low.
FDA Label Information
(See CONTRAINDICATIONS and PRECAUTIONS .) Oral hypoglycemics: The effects of fluconazole on the pharmacokinetics of the sulfonylurea oral hypoglycemic agents tolbutamide, glipizide, and glyburide were evaluated in three placebo-controlled studies in normal volunteers. (See PRECAUTIONS .) Glyburide: The AUC and C max of glyburide (5 mg single dose) were significantly increased following the administration of fluconazole in 20 normal male volunteers. Five subjects required oral glucose following the ingestion of glyburide after 7 days of fluconazole administration.
Glyburide Also Interacts With
- Fluvastatin moderate
- Colesevelam minor
- Eprosartan minor
- Etodolac minor
- Miglitol minor
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Glyburide + Fluconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Glyburide's 9. In the minor band specifically: Glyburide has 8 (also Colesevelam, Eprosartan, Etodolac, Miglitol); Fluconazole has 57 (also Amlodipine, Losartan, Hydrochlorothiazide, Meloxicam).
What mechanism field is on file for Glyburide and Fluconazole?
Fluconazole slows down how the body breaks down glyburide, which causes the diabetes medicine to stay in the blood longer. This can lead to blood sugar levels dropping too low.
Fluconazole carries more major-labeled pairs than Glyburide
SPL source-record counts only. This page's band is minor · classes on file: Glyburide (Sulfonylurea); Fluconazole (Azole Antifungal).
Fluconazole has 3 major-labeled pairs vs Glyburide's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 8 minor · 9 total
- Other minor peers for Glyburide
- Colesevelam
- Eprosartan
- Etodolac
- Miglitol
3 major · 7 moderate · 57 minor · 67 total
- Other minor peers for Fluconazole
- Amlodipine
- Losartan
- Hydrochlorothiazide
- Meloxicam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.