Glyburide and Fluconazole Interaction
Drug interaction information between Glyburide and Fluconazole.
Glyburide and Fluconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Glyburide and Fluconazole. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Fluconazole slows down how the body breaks down glyburide, which causes the diabetes medicine to stay in the blood longer. This can lead to blood sugar levels dropping too low.
What To Do
Monitor your blood sugar levels very closely for signs of hypoglycemia. Your doctor may need to adjust your glyburide dose while you are taking fluconazole.
FDA Label Information
(See CONTRAINDICATIONS and PRECAUTIONS .) Oral hypoglycemics: The effects of fluconazole on the pharmacokinetics of the sulfonylurea oral hypoglycemic agents tolbutamide, glipizide, and glyburide were evaluated in three placebo-controlled studies in normal volunteers. (See PRECAUTIONS .) Glyburide: The AUC and C max of glyburide (5 mg single dose) were significantly increased following the administration of fluconazole in 20 normal male volunteers. Five subjects required oral glucose following the ingestion of glyburide after 7 days of fluconazole administration.
Glyburide Also Interacts With
- Fluvastatin moderate
- Colesevelam minor
- Eprosartan minor
- Etodolac minor
- Miglitol minor
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Frequently Asked Questions
Can I take Glyburide and Fluconazole together?
This is a minor interaction. Monitor your blood sugar levels very closely for signs of hypoglycemia. Your doctor may need to adjust your glyburide dose while you are taking fluconazole.
How serious is the interaction between Glyburide and Fluconazole?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Glyburide and Fluconazole interact?
Fluconazole slows down how the body breaks down glyburide, which causes the diabetes medicine to stay in the blood longer. This can lead to blood sugar levels dropping too low.
Understanding the Glyburide and Fluconazole Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Glyburide belongs to the Sulfonylurea class and Fluconazole belongs to the Azole Antifungal class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Fluconazole slows down how the body breaks down glyburide, which causes the diabetes medicine to stay in the blood longer. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Glyburide has 9 total documented interactions on file in this dataset, and Fluconazole has 67. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Monitor your blood sugar levels very closely for signs of hypoglycemia. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Glyburide or Fluconazole based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.