Miglitol and Metformin Interaction
Drug interaction information between Miglitol and Metformin.
Miglitol and Metformin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Miglitol and Metformin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Miglitol may slightly lower the amount of metformin that enters your bloodstream, but the change is usually not large enough to matter.
FDA Label Information
The effect of miglitol (100 mg 3 times daily for 7 days) on the pharmacokinetics of a single 1000 mg dose of metformin was investigated in healthy volunteers. Mean AUC and C max values for metformin were 12% to 13% lower when the volunteers were given miglitol as compared with placebo, but this difference was not statistically significant.
Miglitol Also Interacts With
- Propranolol minor
- Warfarin minor
- Nifedipine minor
- Glyburide minor
- Ranitidine minor
Metformin Also Interacts With
- Bictegravir/Emtricitabine/Tenofovir moderate
- Dolutegravir/Lamivudine moderate
- Empagliflozin moderate
- Empagliflozin/Linagliptin moderate
- Ertugliflozin moderate
Frequently Asked Questions
What SPL severity band is on file for Miglitol + Metformin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Metformin has 27 labeled pairs on file vs Miglitol's 7. In the minor band specifically: Miglitol has 7 (also Propranolol, Warfarin, Nifedipine, Glyburide); Metformin has 17 (also Topiramate, Dolutegravir, Ranolazine, Cimetidine).
What mechanism field is on file for Miglitol and Metformin?
Miglitol may slightly lower the amount of metformin that enters your bloodstream, but the change is usually not large enough to matter.
Metformin's labeled portfolio outnumbers Miglitol
SPL source-record counts only. This page's band is minor · classes on file: Miglitol (Alpha-Glucosidase Inhibitor); Metformin (Biguanide).
0 major · 0 moderate · 7 minor · 7 total
- Other minor peers for Miglitol
- Propranolol
- Warfarin
- Nifedipine
- Glyburide
0 major · 10 moderate · 17 minor · 27 total
- Other minor peers for Metformin
- Topiramate
- Dolutegravir
- Ranolazine
- Cimetidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.