Glyburide and Etodolac Interaction
Drug interaction information between Glyburide and Etodolac.
Glyburide and Etodolac have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Glyburide and Etodolac. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
These two drugs do not seem to affect how the body processes or removes each other. There is no known interaction between them based on current studies.
What To Do
No special changes are usually needed when taking these two drugs together. Continue to follow your doctor's instructions for both medications.
FDA Label Information
Glyburide Etodolac has no apparent pharmacokinetic interaction when administered with glyburide.
Glyburide Also Interacts With
- Fluvastatin moderate
- Colesevelam minor
- Eprosartan minor
- Fluconazole minor
- Miglitol minor
Etodolac Also Interacts With
- Warfarin moderate
- Hydrochlorothiazide minor
- Furosemide minor
- Aspirin minor
- Methotrexate minor
Frequently Asked Questions
Can I take Glyburide and Etodolac together?
This is a minor interaction. No special changes are usually needed when taking these two drugs together. Continue to follow your doctor's instructions for both medications.
How serious is the interaction between Glyburide and Etodolac?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Glyburide and Etodolac interact?
These two drugs do not seem to affect how the body processes or removes each other. There is no known interaction between them based on current studies.
Understanding the Glyburide and Etodolac Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Glyburide belongs to the Sulfonylurea class and Etodolac belongs to the Nonsteroidal Anti-Inflammatory Drug (NSAID) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: These two drugs do not seem to affect how the body processes or removes each other. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Glyburide has 9 total documented interactions on file in this dataset, and Etodolac has 10. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: No special changes are usually needed when taking these two drugs together. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Glyburide or Etodolac based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.