glyburide vs miglitol
Side-by-side comparison of glyburide and miglitol. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Drug Interactions Several studies investigated the possible interaction between miglitol and glyburide. In six healthy volunteers given a single dose of 5 mg glyburide on a background of 6 days treatment with miglitol (50 mg 3 times daily for 4 days followed by 100 mg 3 times daily for 2 days) or placebo, the mean C max and AUC values for glyburide were 17% and 25% lower, respectively, when glyburide was given with miglitol. In a study in diabetic patients in which the effects of adding miglitol 100 mg 3 times daily for 7 days or placebo to a background regimen of 3.5 mg glyburide daily...
Recommendation: Your doctor may need to check your blood sugar more often and adjust your dose.
Glyburide is a medicine that helps lower blood sugar in adults with type 2 diabetes. It works along with diet and exercise.
Miglitol (Glyset) helps control blood sugar in adults with type 2 diabetes. It should be used with diet and exercise.
Glyburide is used to help control blood sugar levels in adults who have type 2 diabetes. It is prescribed in addition to diet and exercise. This medicine helps your body use insulin better, which lowers your blood sugar.
Miglitol treats type 2 diabetes. It helps lower your blood sugar levels after meals. You should use it along with a healthy diet and regular exercise to manage your diabetes.
Glyburide belongs to a class of drugs called sulfonylureas. It works by helping your pancreas release more insulin. Insulin then helps move sugar from your blood into your cells for energy.
Miglitol slows down the digestion of carbohydrates. This helps to prevent a large rise in blood sugar after you eat. It works in your gut to block certain enzymes.
- • Nausea
- • Heartburn
- • Fullness in your upper abdomen
- • Gas
- • Diarrhea
- • Abdominal pain
- High blood sugar 3,038
- Feeling sick to your stomach 2,020
- Weight loss 1,536
- Loose stools 1,282
- Feeling lightheaded 1,201
- Low blood sugar 67
- Abnormal liver function 46
- Reduced appetite 39
- Diarrhea 37
- Kidney problems 37
Oral diabetes medicines like glyburide may increase your risk of heart problems, compared to treatment with diet alone or diet plus insulin. Talk to your doctor about the risks and benefits of taking glyburide.
No specific warnings noted.
Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if glyburide will harm your unborn baby. Talk to your doctor if you are breastfeeding.
There is not enough information about the safety of miglitol during pregnancy or breastfeeding. Talk to your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.
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How to Read This glyburide vs miglitol Comparison
glyburide is classified in the Sulfonylurea drug class, while miglitol sits within the Alpha-Glucosidase Inhibitor class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, glyburide has 9,077 submissions while miglitol has 226. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to miglitol can lower the amount of glyburide that enters your blood.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between glyburide and miglitol - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.