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What the FDA labels say about taking them together

Atropine and mexiletine

Atropine's FDA label of May 18, 2026 names mexiletine in its drug interactions section; the mexiletine label PlainMeds reads does not name atropine. The atropine label: “DRUG INTERACTIONS Mexiletine: Decreases rate of mexiletine absorption.”

Check it at the source: the atropine FDA label on DailyMed (effective May 18, 2026, Hospira, Inc.); the mexiletine FDA label on DailyMed (effective May 14, 2026, Macleods Pharmaceuticals Limited).

What does the atropine label say about mexiletine?

Atropine label, drug interactions

DRUG INTERACTIONS Mexiletine: Decreases rate of mexiletine absorption.

Source: FDA drug label (Atropine Sulfate), Hospira, Inc., effective May 18, 2026 (SPL set ad8916e7-206e-409e-2582-30d072845dd4), via openFDA; the full label on DailyMed

What does the mexiletine label say about atropine?

Mexiletine's label (effective May 14, 2026) does not name atropine in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Mexiletine Hydrochloride), Macleods Pharmaceuticals Limited, effective May 14, 2026 (SPL set a61a07f6-0b48-4dcd-ad42-5d90f6e69ab1), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

22Atropine generic labelers
14Mexiletine generic labelers
AtropineMexiletine
Labeled forn/an/a
Boxed warningNoNo
Pharmacy cost (NADAC)$7.74 per mL 1% eye drops$0.222 per capsule 150 mg capsule
Shortage nowIn shortageNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?