Atropine and Mexiletine Interaction
Drug interaction information between Atropine and Mexiletine.
Atropine and Mexiletine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Atropine and Mexiletine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Atropine slows down the movement of the stomach, which makes it take longer for mexiletine to be absorbed into the body.
FDA Label Information
7 DRUG INTERACTIONS 7.1 Mexiletine Atropine Sulfate Injection decreased the rate of mexiletine absorption without altering the relative oral bioavailability; this delay in mexiletine absorption was reversed by the combination of atropine and intravenous metoclopramide during pretreatment for anesthesia.
Atropine Also Interacts With
- Metoclopramide minor
- Imipramine minor
- Midazolam minor
- Nabilone minor
- Pramlintide minor
Mexiletine Also Interacts With
- Lidocaine Topical moderate
- Propranolol minor
- Digoxin minor
- Propafenone minor
- Theophylline minor
Frequently Asked Questions
What SPL severity band is on file for Atropine + Mexiletine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Mexiletine has 14 labeled pairs on file vs Atropine's 6. In the minor band specifically: Atropine has 6 (also Metoclopramide, Imipramine, Midazolam, Nabilone); Mexiletine has 13 (also Propranolol, Digoxin, Propafenone, Theophylline).
What mechanism field is on file for Atropine and Mexiletine?
Atropine slows down the movement of the stomach, which makes it take longer for mexiletine to be absorbed into the body.
Mexiletine's labeled portfolio outnumbers Atropine
SPL source-record counts only. This page's band is minor · classes on file: Atropine (Anticholinergic); Mexiletine (Class IB Antiarrhythmic).
0 major · 0 moderate · 6 minor · 6 total
- Other minor peers for Atropine
- Metoclopramide
- Imipramine
- Midazolam
- Nabilone
0 major · 1 moderate · 13 minor · 14 total
- Other minor peers for Mexiletine
- Propranolol
- Digoxin
- Propafenone
- Theophylline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.