Atropine and Nabilone Interaction
Drug interaction information between Atropine and Nabilone.
Atropine and Nabilone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Atropine and Nabilone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs can cause a fast heartbeat and sleepiness, and taking them together makes these side effects much stronger.
FDA Label Information
CONCOMITANT DRUG CLINICAL EFFECT(S) Amphetamines, cocaine, other sympathomimetic agents Additive hypertension, tachycardia, possibly cardiotoxicity Atropine, scopolamine, antihistamines, other anticholinergic agents Additive or super-additive tachycardia, drowsiness Amitriptyline, amoxapine, desipramine, other tricyclic antidepressants Additive tachycardia, hypertension, drowsiness Barbiturates, benzodiazepines, ethanol, lithium, opioids, buspirone, antihistamines, muscle relaxants, other CNS depressants Additive drowsiness and CNS depression Disulfiram A reversible hypomanic reaction was...
Atropine Also Interacts With
- Mexiletine minor
- Metoclopramide minor
- Imipramine minor
- Midazolam minor
- Pramlintide minor
Nabilone Also Interacts With
- Fluoxetine minor
- Buspirone minor
- Amitriptyline minor
- Diazepam minor
- Lithium minor
Frequently Asked Questions
What SPL severity band is on file for Atropine + Nabilone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nabilone has 11 labeled pairs on file vs Atropine's 6. In the minor band specifically: Atropine has 6 (also Mexiletine, Metoclopramide, Imipramine, Midazolam); Nabilone has 11 (also Fluoxetine, Buspirone, Amitriptyline, Diazepam).
What mechanism field is on file for Atropine and Nabilone?
Both drugs can cause a fast heartbeat and sleepiness, and taking them together makes these side effects much stronger.
Nabilone's labeled portfolio outnumbers Atropine
SPL source-record counts only. This page's band is minor · classes on file: Atropine (Anticholinergic); Nabilone (Cannabinoid Antiemetic).
0 major · 0 moderate · 6 minor · 6 total
- Other minor peers for Atropine
- Mexiletine
- Metoclopramide
- Imipramine
- Midazolam
0 major · 0 moderate · 11 minor · 11 total
- Other minor peers for Nabilone
- Fluoxetine
- Buspirone
- Amitriptyline
- Diazepam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.