Metformin/Pioglitazone and Metformin Interaction
Drug interaction information between Metformin/Pioglitazone and Metformin.
Metformin/Pioglitazone and Metformin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Metformin/Pioglitazone and Metformin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking two medicines that both contain metformin can cause too much of the drug to build up in your body.
FDA Label Information
( 7.3 ) Drugs that reduce metformin clearance (such as ranolazine, vandetanib, dolutegravir, and cimetidine), may increase the accumulation of metformin. Therefore, the maximum recommended dosage of ACTOPLUS MET is 15 mg of pioglitazone and 850 mg of metformin HCl once daily if used in combination with gemfibrozil or other strong CYP2C8 inhibitors [see Dosage and Administration (2.3) , Clinical Pharmacology (12.3) ] . Therefore, if an inducer of CYP2C8 is started or stopped during treatment with ACTOPLUS MET, changes in diabetes treatment may be needed based on clinical response without...
Metformin/Pioglitazone Also Interacts With
- Dolutegravir moderate
- Ranolazine moderate
- Cimetidine moderate
- Topiramate minor
- Pioglitazone minor
Metformin Also Interacts With
- Bictegravir/Emtricitabine/Tenofovir moderate
- Dolutegravir/Lamivudine moderate
- Empagliflozin moderate
- Empagliflozin/Linagliptin moderate
- Ertugliflozin moderate
Frequently Asked Questions
What SPL severity band is on file for Metformin/Pioglitazone + Metformin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Metformin has 27 labeled pairs on file vs Metformin/Pioglitazone's 10. In the minor band specifically: Metformin/Pioglitazone has 7 (also Topiramate, Pioglitazone, Rifampin, Gemfibrozil); Metformin has 17 (also Topiramate, Dolutegravir, Ranolazine, Cimetidine).
What mechanism field is on file for Metformin/Pioglitazone and Metformin?
Taking two medicines that both contain metformin can cause too much of the drug to build up in your body.
Metformin's labeled portfolio outnumbers Metformin/Pioglitazone
SPL source-record counts only. This page's band is minor · classes on file: Metformin/Pioglitazone (Biguanide / TZD Combination); Metformin (Biguanide).
0 major · 3 moderate · 7 minor · 10 total
- Other minor peers for Metformin/Pioglitazone
- Topiramate
- Pioglitazone
- Rifampin
- Gemfibrozil
0 major · 10 moderate · 17 minor · 27 total
- Other minor peers for Metformin
- Topiramate
- Dolutegravir
- Ranolazine
- Cimetidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.