Metformin/Pioglitazone and Rifampin Interaction
Drug interaction information between Metformin/Pioglitazone and Rifampin.
Metformin/Pioglitazone and Rifampin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Metformin/Pioglitazone and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin causes your body to break down pioglitazone much faster than normal, which can lower the amount of medicine in your system.
FDA Label Information
( 7.1 ) CYP2C8 inducers (e.g., rifampin) may decrease pioglitazone concentrations. 7.2 CYP2C8 Inducers An inducer of CYP2C8 (e.g., rifampin) may significantly decrease the exposure (AUC) of pioglitazone.
Metformin/Pioglitazone Also Interacts With
- Dolutegravir moderate
- Ranolazine moderate
- Cimetidine moderate
- Metformin minor
- Topiramate minor
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Metformin/Pioglitazone + Rifampin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Metformin/Pioglitazone's 10. In the minor band specifically: Metformin/Pioglitazone has 7 (also Metformin, Topiramate, Pioglitazone, Gemfibrozil); Rifampin has 103 (also Metoprolol, Losartan, Simvastatin, Glipizide).
What mechanism field is on file for Metformin/Pioglitazone and Rifampin?
Rifampin causes your body to break down pioglitazone much faster than normal, which can lower the amount of medicine in your system.
Rifampin carries more major-labeled pairs than Metformin/Pioglitazone
SPL source-record counts only. This page's band is minor · classes on file: Metformin/Pioglitazone (Biguanide / TZD Combination); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Metformin/Pioglitazone's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 7 minor · 10 total
- Other minor peers for Metformin/Pioglitazone
- Metformin
- Topiramate
- Pioglitazone
- Gemfibrozil
8 major · 26 moderate · 103 minor · 137 total
- Other minor peers for Rifampin
- Metoprolol
- Losartan
- Simvastatin
- Glipizide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.