Metformin/Pioglitazone and Pioglitazone Interaction
Drug interaction information between Metformin/Pioglitazone and Pioglitazone.
Metformin/Pioglitazone and Pioglitazone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Metformin/Pioglitazone and Pioglitazone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Other medications can change how your body processes pioglitazone, leading to levels that are either too high or too low.
FDA Label Information
( 7.1 ) CYP2C8 inducers (e.g., rifampin) may decrease pioglitazone concentrations. ( 7.6 ) Topiramate may decrease pioglitazone concentrations. ( 7.8 ) 7.1 Strong CYP2C8 Inhibitors An inhibitor of CYP2C8 (e.g., gemfibrozil) significantly increases the exposure (area under the serum concentration-time curve or AUC) and half-life (t ½ ) of pioglitazone.
Metformin/Pioglitazone Also Interacts With
- Dolutegravir moderate
- Ranolazine moderate
- Cimetidine moderate
- Metformin minor
- Topiramate minor
Pioglitazone Also Interacts With
- Clarithromycin major
- Rifampin minor
- Gemfibrozil minor
- Abiraterone minor
- Dapagliflozin minor
Frequently Asked Questions
What SPL severity band is on file for Metformin/Pioglitazone + Pioglitazone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
How many labeled pairs sit in each drug's minor band?
Metformin/Pioglitazone and Pioglitazone tie at 10 labeled pairs each. minor-band counts: Metformin/Pioglitazone 7 alongside Metformin, Topiramate, Rifampin, Gemfibrozil; Pioglitazone 9 alongside Rifampin, Gemfibrozil, Abiraterone, Dapagliflozin.
What mechanism field is on file for Metformin/Pioglitazone and Pioglitazone?
Other medications can change how your body processes pioglitazone, leading to levels that are either too high or too low.
Pioglitazone carries more major-labeled pairs than Metformin/Pioglitazone
SPL source-record counts only. This page's band is minor · classes on file: Metformin/Pioglitazone (Biguanide / TZD Combination); Pioglitazone (Thiazolidinedione).
Pioglitazone has 1 major-labeled pair vs Metformin/Pioglitazone's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 7 minor · 10 total
- Other minor peers for Metformin/Pioglitazone
- Metformin
- Topiramate
- Rifampin
- Gemfibrozil
1 major · 0 moderate · 9 minor · 10 total
- Other minor peers for Pioglitazone
- Rifampin
- Gemfibrozil
- Abiraterone
- Dapagliflozin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.