Metformin/Pioglitazone and Dolutegravir Interaction
Drug interaction information between Metformin/Pioglitazone and Dolutegravir.
Metformin/Pioglitazone and Dolutegravir have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Metformin/Pioglitazone and Dolutegravir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Dolutegravir interferes with how your kidneys remove metformin from your body, causing the drug to stay in your system longer. This can lead to a dangerous buildup of acid in your blood.
FDA Label Information
( 7.3 ) Drugs that reduce metformin clearance (such as ranolazine, vandetanib, dolutegravir, and cimetidine), may increase the accumulation of metformin. 7.4 Drugs that Reduce Metformin Clearance Concomitant use of drugs that interfere with common renal tubular transport systems involved in the renal elimination of metformin (e.g., organic cationic transporter-2 [OCT2]/multidrug and toxin extrusion [MATE] inhibitors such as ranolazine, vandetanib, dolutegravir, and cimetidine) could increase systemic exposure to metformin and may increase the risk for lactic acidosis [see Clinical...
Metformin/Pioglitazone Also Interacts With
- Ranolazine moderate
- Cimetidine moderate
- Metformin minor
- Topiramate minor
- Pioglitazone minor
Dolutegravir Also Interacts With
- Dofetilide major
- Empagliflozin moderate
- Empagliflozin/Linagliptin moderate
- Ertugliflozin moderate
- Linagliptin moderate
Frequently Asked Questions
What SPL severity band is on file for Metformin/Pioglitazone + Dolutegravir?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Dolutegravir has 28 labeled pairs on file vs Metformin/Pioglitazone's 10. In the moderate band specifically: Metformin/Pioglitazone has 3 (also Ranolazine, Cimetidine); Dolutegravir has 6 (also Empagliflozin, Empagliflozin/Linagliptin, Ertugliflozin, Linagliptin).
What mechanism field is on file for Metformin/Pioglitazone and Dolutegravir?
Dolutegravir interferes with how your kidneys remove metformin from your body, causing the drug to stay in your system longer. This can lead to a dangerous buildup of acid in your blood.
Dolutegravir carries more major-labeled pairs than Metformin/Pioglitazone
SPL source-record counts only. This page's band is moderate · classes on file: Metformin/Pioglitazone (Biguanide / TZD Combination); Dolutegravir (Integrase Strand Transfer Inhibitor).
Dolutegravir has 1 major-labeled pair vs Metformin/Pioglitazone's 0. This page itself is in the moderate band, not the major band.
0 major · 3 moderate · 7 minor · 10 total
- Other moderate peers for Metformin/Pioglitazone
- Ranolazine
- Cimetidine
1 major · 6 moderate · 21 minor · 28 total
- Other moderate peers for Dolutegravir
- Empagliflozin
- Empagliflozin/Linagliptin
- Ertugliflozin
- Linagliptin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.