Metformin/Pioglitazone and Gemfibrozil Interaction
Drug interaction information between Metformin/Pioglitazone and Gemfibrozil.
Metformin/Pioglitazone and Gemfibrozil have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Metformin/Pioglitazone and Gemfibrozil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Gemfibrozil blocks the way your body clears pioglitazone, which can cause the medicine to reach high levels in your blood.
FDA Label Information
7 DRUG INTERACTIONS Strong CYP2C8 inhibitors (e.g., gemfibrozil): Limit ACTOPLUS MET dose to 15 mg/850 mg daily. ( 7.8 ) 7.1 Strong CYP2C8 Inhibitors An inhibitor of CYP2C8 (e.g., gemfibrozil) significantly increases the exposure (area under the serum concentration-time curve or AUC) and half-life (t ½ ) of pioglitazone. Therefore, the maximum recommended dosage of ACTOPLUS MET is 15 mg of pioglitazone and 850 mg of metformin HCl once daily if used in combination with gemfibrozil or other strong CYP2C8 inhibitors [see Dosage and Administration (2.3) , Clinical Pharmacology (12.3) ] .
Metformin/Pioglitazone Also Interacts With
- Dolutegravir moderate
- Ranolazine moderate
- Cimetidine moderate
- Metformin minor
- Topiramate minor
Gemfibrozil Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Repaglinide major
- Simvastatin major
- Atorvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Metformin/Pioglitazone + Gemfibrozil?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Gemfibrozil has 20 labeled pairs on file vs Metformin/Pioglitazone's 10. In the minor band specifically: Metformin/Pioglitazone has 7 (also Metformin, Topiramate, Pioglitazone, Rifampin); Gemfibrozil has 8 (also Colchicine, Colestipol, Enzalutamide, Montelukast).
What mechanism field is on file for Metformin/Pioglitazone and Gemfibrozil?
Gemfibrozil blocks the way your body clears pioglitazone, which can cause the medicine to reach high levels in your blood.
Gemfibrozil carries more major-labeled pairs than Metformin/Pioglitazone
SPL source-record counts only. This page's band is minor · classes on file: Metformin/Pioglitazone (Biguanide / TZD Combination); Gemfibrozil (Fibrate).
Gemfibrozil has 4 major-labeled pairs vs Metformin/Pioglitazone's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 7 minor · 10 total
- Other minor peers for Metformin/Pioglitazone
- Metformin
- Topiramate
- Pioglitazone
- Rifampin
4 major · 8 moderate · 8 minor · 20 total
- Other minor peers for Gemfibrozil
- Colchicine
- Colestipol
- Enzalutamide
- Montelukast
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.