Metformin/Empagliflozin and Lithium Interaction
Drug interaction information between Metformin/Empagliflozin and Lithium.
Metformin/Empagliflozin and Lithium have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Metformin/Empagliflozin and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Empagliflozin can cause the body to remove lithium through the urine more quickly, which lowers the amount of lithium in your blood.
FDA Label Information
Lithium Clinical Impact Concomitant use of an SGLT2 inhibitor with lithium may decrease serum lithium concentrations. Intervention Monitor serum lithium concentration more frequently during SYNJARDY or SYNJARDY XR initiation and dosage changes.
Metformin/Empagliflozin Also Interacts With
- Metformin moderate
- Dolutegravir moderate
- Ranolazine moderate
- Cimetidine moderate
- Empagliflozin moderate
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Metformin/Empagliflozin + Lithium?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Metformin/Empagliflozin's 9. In the minor band specifically: Metformin/Empagliflozin has 4 (also Topiramate, Phenytoin, Zonisamide); Lithium has 65 (also Aripiprazole, Asenapine, Canagliflozin, Candesartan).
What mechanism field is on file for Metformin/Empagliflozin and Lithium?
Empagliflozin can cause the body to remove lithium through the urine more quickly, which lowers the amount of lithium in your blood.
Lithium carries more major-labeled pairs than Metformin/Empagliflozin
SPL source-record counts only. This page's band is minor · classes on file: Metformin/Empagliflozin (Biguanide / SGLT2 Combination); Lithium (Mood Stabilizer).
Lithium has 2 major-labeled pairs vs Metformin/Empagliflozin's 0. This page itself is in the minor band, not the major band.
0 major · 5 moderate · 4 minor · 9 total
- Other minor peers for Metformin/Empagliflozin
- Topiramate
- Phenytoin
- Zonisamide
2 major · 23 moderate · 65 minor · 90 total
- Other minor peers for Lithium
- Aripiprazole
- Asenapine
- Canagliflozin
- Candesartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.