Metformin/Empagliflozin and Empagliflozin Interaction
Drug interaction information between Metformin/Empagliflozin and Empagliflozin.
Metformin/Empagliflozin and Empagliflozin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Metformin/Empagliflozin and Empagliflozin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking certain medications like topiramate along with your diabetes medicine can lower your blood's ability to balance acid. This increases the risk of a serious condition called lactic acidosis.
FDA Label Information
7 DRUG INTERACTIONS See Table 4 for clinically relevant interactions with SYNJARDY or SYNJARDY XR. Table 4 Clinically Relevant Interactions with SYNJARDY or SYNJARDY XR Carbonic Anhydrase Inhibitors Clinical Impact Topiramate or other carbonic anhydrase inhibitors (e.g., zonisamide, acetazolamide or dichlorphenamide) frequently causes a decrease in serum bicarbonate and induce non-anion gap, hyperchloremic metabolic acidosis. Concomitant use of these drugs with SYNJARDY or SYNJARDY XR may increase the risk of lactic acidosis.
Metformin/Empagliflozin Also Interacts With
- Metformin moderate
- Dolutegravir moderate
- Ranolazine moderate
- Cimetidine moderate
- Topiramate minor
Empagliflozin Also Interacts With
- Metformin moderate
- Dolutegravir moderate
- Ranolazine moderate
- Cimetidine moderate
- Topiramate minor
Frequently Asked Questions
What SPL severity band is on file for Metformin/Empagliflozin + Empagliflozin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Empagliflozin has 10 labeled pairs on file vs Metformin/Empagliflozin's 9. In the moderate band specifically: Metformin/Empagliflozin has 5 (also Metformin, Dolutegravir, Ranolazine, Cimetidine); Empagliflozin has 5 (also Metformin, Dolutegravir, Ranolazine, Cimetidine).
What mechanism field is on file for Metformin/Empagliflozin and Empagliflozin?
Taking certain medications like topiramate along with your diabetes medicine can lower your blood's ability to balance acid. This increases the risk of a serious condition called lactic acidosis.
Empagliflozin's labeled portfolio outnumbers Metformin/Empagliflozin
SPL source-record counts only. This page's band is moderate · classes on file: Metformin/Empagliflozin (Biguanide / SGLT2 Combination); Empagliflozin (SGLT2 Inhibitor).
0 major · 5 moderate · 4 minor · 9 total
- Other moderate peers for Metformin/Empagliflozin
- Metformin
- Dolutegravir
- Ranolazine
- Cimetidine
0 major · 5 moderate · 5 minor · 10 total
- Other moderate peers for Empagliflozin
- Metformin
- Dolutegravir
- Ranolazine
- Cimetidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.