Metformin/Empagliflozin and Zonisamide Interaction
Drug interaction information between Metformin/Empagliflozin and Zonisamide.
Metformin/Empagliflozin and Zonisamide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Metformin/Empagliflozin and Zonisamide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Zonisamide can cause an acid buildup in the blood, which increases the risk of a serious condition called metabolic acidosis when taken with metformin.
Metformin/Empagliflozin Also Interacts With
- Metformin moderate
- Dolutegravir moderate
- Ranolazine moderate
- Cimetidine moderate
- Empagliflozin moderate
Zonisamide Also Interacts With
- Alogliptin moderate
- Ertugliflozin moderate
- Topiramate moderate
- Carbamazepine minor
- Empagliflozin minor
Frequently Asked Questions
What SPL severity band is on file for Metformin/Empagliflozin + Zonisamide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Zonisamide has 13 labeled pairs on file vs Metformin/Empagliflozin's 9. In the minor band specifically: Metformin/Empagliflozin has 4 (also Topiramate, Lithium, Phenytoin); Zonisamide has 10 (also Carbamazepine, Empagliflozin, Empagliflozin/Linagliptin, Linagliptin).
What mechanism field is on file for Metformin/Empagliflozin and Zonisamide?
Zonisamide can cause an acid buildup in the blood, which increases the risk of a serious condition called metabolic acidosis when taken with metformin.
Zonisamide's labeled portfolio outnumbers Metformin/Empagliflozin
SPL source-record counts only. This page's band is minor · classes on file: Metformin/Empagliflozin (Biguanide / SGLT2 Combination); Zonisamide (Anticonvulsant (Sulfonamide)).
0 major · 5 moderate · 4 minor · 9 total
- Other minor peers for Metformin/Empagliflozin
- Topiramate
- Lithium
- Phenytoin
0 major · 3 moderate · 10 minor · 13 total
- Other minor peers for Zonisamide
- Carbamazepine
- Empagliflozin
- Empagliflozin/Linagliptin
- Linagliptin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.