Metformin/Empagliflozin and Metformin Interaction
Drug interaction information between Metformin/Empagliflozin and Metformin.
Metformin/Empagliflozin and Metformin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Metformin/Empagliflozin and Metformin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking substances that interfere with how the kidneys remove metformin can cause the drug to build up to dangerous levels. This increases the risk of a serious condition where too much acid builds up in the blood.
FDA Label Information
Drugs that Reduce Metformin Clearance Clinical Impact Concomitant use of drugs that interfere with common renal tubular transport systems involved in the renal elimination of metformin (e.g., organic cationic transporter-2 [OCT2] / multidrug and toxin extrusion [MATE] inhibitors such as ranolazine, vandetanib, dolutegravir, and cimetidine) could increase systemic exposure to metformin and may increase the risk for lactic acidosis [see Clinical Pharmacology (12.3) ] . Alcohol Clinical Impact Alcohol is known to potentiate the effect of metformin on lactate metabolism. ( 7 ) Drugs that...
Metformin/Empagliflozin Also Interacts With
- Dolutegravir moderate
- Ranolazine moderate
- Cimetidine moderate
- Empagliflozin moderate
- Topiramate minor
Metformin Also Interacts With
- Bictegravir/Emtricitabine/Tenofovir moderate
- Dolutegravir/Lamivudine moderate
- Empagliflozin moderate
- Empagliflozin/Linagliptin moderate
- Ertugliflozin moderate
Frequently Asked Questions
What SPL severity band is on file for Metformin/Empagliflozin + Metformin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Metformin has 27 labeled pairs on file vs Metformin/Empagliflozin's 9. In the moderate band specifically: Metformin/Empagliflozin has 5 (also Dolutegravir, Ranolazine, Cimetidine, Empagliflozin); Metformin has 10 (also Bictegravir, Dolutegravir/Lamivudine, Empagliflozin, Empagliflozin/Linagliptin).
What mechanism field is on file for Metformin/Empagliflozin and Metformin?
Taking substances that interfere with how the kidneys remove metformin can cause the drug to build up to dangerous levels. This increases the risk of a serious condition where too much acid builds up in the blood.
Metformin's labeled portfolio outnumbers Metformin/Empagliflozin
SPL source-record counts only. This page's band is moderate · classes on file: Metformin/Empagliflozin (Biguanide / SGLT2 Combination); Metformin (Biguanide).
0 major · 5 moderate · 4 minor · 9 total
- Other moderate peers for Metformin/Empagliflozin
- Dolutegravir
- Ranolazine
- Cimetidine
- Empagliflozin
0 major · 10 moderate · 17 minor · 27 total
- Other moderate peers for Metformin
- Bictegravir
- Dolutegravir/Lamivudine
- Empagliflozin
- Empagliflozin/Linagliptin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.