Metformin/Empagliflozin and Topiramate Interaction
Drug interaction information between Metformin/Empagliflozin and Topiramate.
Metformin/Empagliflozin and Topiramate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Metformin/Empagliflozin and Topiramate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Topiramate can lower the amount of bicarbonate in your blood and make it more acidic, which increases the risk of a dangerous condition.
Metformin/Empagliflozin Also Interacts With
- Metformin moderate
- Dolutegravir moderate
- Ranolazine moderate
- Cimetidine moderate
- Empagliflozin moderate
Topiramate Also Interacts With
- Zonisamide moderate
- Alogliptin moderate
- Ertugliflozin moderate
- Hydrochlorothiazide minor
- Amitriptyline minor
Frequently Asked Questions
What SPL severity band is on file for Metformin/Empagliflozin + Topiramate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Topiramate has 30 labeled pairs on file vs Metformin/Empagliflozin's 9. In the minor band specifically: Metformin/Empagliflozin has 4 (also Lithium, Phenytoin, Zonisamide); Topiramate has 27 (also Hydrochlorothiazide, Amitriptyline, Pioglitazone, Carbamazepine).
What mechanism field is on file for Metformin/Empagliflozin and Topiramate?
Topiramate can lower the amount of bicarbonate in your blood and make it more acidic, which increases the risk of a dangerous condition.
Topiramate's labeled portfolio outnumbers Metformin/Empagliflozin
SPL source-record counts only. This page's band is minor · classes on file: Metformin/Empagliflozin (Biguanide / SGLT2 Combination); Topiramate (Anticonvulsant).
0 major · 5 moderate · 4 minor · 9 total
- Other minor peers for Metformin/Empagliflozin
- Lithium
- Phenytoin
- Zonisamide
0 major · 3 moderate · 27 minor · 30 total
- Other minor peers for Topiramate
- Hydrochlorothiazide
- Amitriptyline
- Pioglitazone
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.