Itraconazole and Felodipine Interaction
Drug interaction information between Itraconazole and Felodipine.
Itraconazole and Felodipine have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Itraconazole and Felodipine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole stops the body from breaking down felodipine, which can lead to dangerously high levels of the blood pressure medicine in your system.
FDA Label Information
Calcium Channel Blockers Felodipine a Nisoldipine Contraindicated during and 2 weeks after itraconazole treatment.
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Felodipine Also Interacts With
- Theophylline major
- Nirmatrelvir/Ritonavir moderate
- Metoprolol minor
- Spironolactone minor
- Ketoconazole minor
Frequently Asked Questions
What SPL severity band is on file for Itraconazole + Felodipine?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Felodipine's 18. In the major band specifically: Itraconazole has 19 (also Isavuconazonium, Lurasidone, Pimozide, Methadone); Felodipine has 2 (also Theophylline).
What mechanism field is on file for Itraconazole and Felodipine?
Itraconazole stops the body from breaking down felodipine, which can lead to dangerously high levels of the blood pressure medicine in your system.
Itraconazole carries more major-labeled pairs than Felodipine
SPL source-record counts only. This page's band is major · classes on file: Itraconazole (Azole Antifungal); Felodipine (Calcium Channel Blocker).
Itraconazole has 19 major-labeled pairs vs Felodipine's 2.
19 major · 20 moderate · 77 minor · 116 total
- Other major peers for Itraconazole
- Isavuconazonium
- Lurasidone
- Pimozide
- Methadone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.