What the FDA labels say about taking them together
Felodipine and itraconazole
Itraconazole's FDA label of July 13, 2026 names felodipine in its boxed warning section; the felodipine label PlainMeds reads does not name itraconazole. The itraconazole label: “Concomitant administration of TOLSURA and felodipine or nisoldipine is contraindicated”
Check it at the source: the felodipine FDA label on DailyMed (effective August 11, 2026, Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.); the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.).
What does the felodipine label say about itraconazole?
Felodipine's label (effective August 11, 2026) does not name itraconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (FELODIPINE), Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc., effective August 11, 2026 (SPL set 0bef7cf2-012b-4804-ac93-0a8b333035db), via openFDA; the full label on DailyMed
What does the itraconazole label say about felodipine?
Itraconazole label, boxed warningSome examples of drugs that are contraindicated for coadministration with SPORANOX ® Capsules are: methadone, disopyramide, dofetilide, dronedarone, quinidine, isavuconazole, ergot alkaloids (such as dihydroergotamine, ergometrine (ergonovine), ergotamine, methylergometrine (methylergonovine)), irinotecan, lurasidone, oral midazolam, pimozide, triazolam, felodipine, nisoldipine, ivabradine, ranolazine, eplerenone, cisapride, naloxegol, lomitapide, lovastatin, simvastatin, avanafil, ticagrelor, finerenone, voclosporin.
Itraconazole label, drug interactionsCalcium Channel Blockers Felodipine Nisoldipine Contraindicated during and 2 weeks after SPORANOX ® treatment.
Itraconazole label, warningsConcomitant administration of SPORANOX ® and felodipine or nisoldipine is contraindicated.
Tolsura label (Mayne Pharma Commercial LLC, April 23, 2025), warnings and precautionsConcomitant administration of TOLSURA and felodipine or nisoldipine is contraindicated [see Contraindications (4.1), Drug Interactions (7.1) and Adverse Reactions (6.2) ]
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Felodipine | Itraconazole | |
|---|---|---|
| Labeled for | High blood pressure | Fungal infections |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.123 per tablet 5 mg tablet | $0.910 per capsule 100 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once