itraconazole vs lurasidone
Side-by-side comparison of itraconazole and lurasidone. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
Lurasidone Midazolam (oral) a Pimozide Triazolam a Contraindicated during and 2 weeks after itraconazole treatment.
Recommendation: Avoid taking these two drugs together and for at least two weeks after your itraconazole treatment ends.
Sporanox
Latuda
Itraconazole capsules are an antifungal medicine. They treat fungal infections in your body.
Lurasidone (Latuda) is a medicine used to treat schizophrenia and bipolar depression. It helps to balance chemicals in the brain.
Itraconazole treats fungal infections like blastomycosis, histoplasmosis, and aspergillosis. It can help both people with healthy immune systems and those with weakened immune systems. It also treats onychomycosis, a fungal infection of the toenails or fingernails.
Lurasidone is used to treat schizophrenia in adults and teens ages 13-17. It also treats the depressive phase of bipolar disorder in adults and children ages 10-17. In adults, it can be used alone or with lithium or valproate for bipolar depression.
Itraconazole stops fungi from growing. It does this by interfering with the production of a substance fungi need to build their cell membranes. This eventually kills the fungus and clears the infection.
Lurasidone is an atypical antipsychotic. It works by affecting certain chemicals in the brain, such as dopamine and serotonin. This helps to improve mood, thinking, and behavior.
- • Nausea
- • Rash
- • Headache
- • Feeling sleepy
- • Feeling restless and needing to move
- • Nausea
- • Weight gain
- • Trouble sleeping
- Interaction with another medicine 1,118
- Fever 570
- Difficulty breathing 472
- Lung infection 462
- Feeling sick to your stomach 446
- Feeling worried or nervous 1,223
- Feeling strange or not like yourself 1,166
- Feeling sad or hopeless 1,120
- Gaining weight 1,077
- Feeling sleepy 1,066
Itraconazole can cause congestive heart failure. You should not take this medicine if you have heart problems. Itraconazole can also interact with many other medicines. Some of these interactions can be dangerous or even fatal. Check with your doctor about all the medicines you take.
This medicine has two important warnings: * **Increased risk of death in elderly people with dementia:** If you are an older adult with dementia-related psychosis, this medicine may increase your chance of death. Lurasidone is not approved for this condition. * **Increased risk of suicidal thoughts and behaviors:** Antidepressants may increase the risk of suicidal thoughts and behaviors in children, teens, and young adults. Your doctor will need to watch you closely for worsening mood or suicidal thoughts.
You should not take itraconazole if you are pregnant or plan to become pregnant. It can harm your unborn baby. Talk to your doctor about safe alternatives.
Tell your doctor if you are pregnant or plan to become pregnant. Babies born to mothers who take this medicine in the last 3 months of pregnancy may have withdrawal symptoms or other problems after birth. Talk to your doctor about the risks and benefits of taking lurasidone during pregnancy.
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How to Read This itraconazole vs lurasidone Comparison
itraconazole is classified in the Azole Antifungal drug class, while lurasidone sits within the Atypical Antipsychotic class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, itraconazole has 3,068 submissions while lurasidone has 5,652. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to itraconazole stops the enzymes that process lurasidone, leading to a buildup of the medication in your blood.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between itraconazole and lurasidone - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.