Losartan and Hydrochlorothiazide/Losartan Interaction
Drug interaction information between Losartan and Hydrochlorothiazide/Losartan.
Losartan and Hydrochlorothiazide/Losartan have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Losartan and Hydrochlorothiazide/Losartan. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these medications together can cause your potassium levels to become dangerously high or lead to kidney problems.
FDA Label Information
( 7.5 ) 7.1 Agents Increasing Serum Potassium Coadministration of losartan with other drugs that raise serum potassium levels may result in hyperkalemia. 7.3 Non-Steroidal Anti-Inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors Losartan Potassium In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with angiotensin II receptor antagonists (including losartan) may result in deterioration of renal function, including possible acute renal...
Losartan Also Interacts With
- Aliskiren major
- Lithium moderate
- Fluconazole minor
- Glecaprevir/Pibrentasvir minor
- Hydrochlorothiazide minor
Hydrochlorothiazide/Losartan Also Interacts With
- Aliskiren major
- Lithium moderate
- Lisinopril minor
- Hydrochlorothiazide minor
- Cholestyramine minor
Frequently Asked Questions
What SPL severity band is on file for Losartan + Hydrochlorothiazide/Losartan?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Losartan has 10 labeled pairs on file vs Hydrochlorothiazide/Losartan's 7. In the minor band specifically: Losartan has 8 (also Fluconazole, Glecaprevir/Pibrentasvir, Hydrochlorothiazide, Hydrochlorothiazide); Hydrochlorothiazide/Losartan has 5 (also Lisinopril, Hydrochlorothiazide, Cholestyramine, Colestipol).
What mechanism field is on file for Losartan and Hydrochlorothiazide/Losartan?
Taking these medications together can cause your potassium levels to become dangerously high or lead to kidney problems.
Losartan's labeled portfolio outnumbers Hydrochlorothiazide/Losartan
SPL source-record counts only. This page's band is minor · classes on file: Losartan (Angiotensin II Receptor Blocker (ARB)); Hydrochlorothiazide/Losartan (Thiazide Diuretic / ARB Combination).
1 major · 1 moderate · 8 minor · 10 total
- Other minor peers for Losartan
- Fluconazole
- Glecaprevir/Pibrentasvir
- Hydrochlorothiazide
- Hydrochlorothiazide
1 major · 1 moderate · 5 minor · 7 total
- Other minor peers for Hydrochlorothiazide/Losartan
- Lisinopril
- Hydrochlorothiazide
- Cholestyramine
- Colestipol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.