Losartan and Hydrochlorothiazide Interaction
Drug interaction information between Losartan and Hydrochlorothiazide.
Losartan and Hydrochlorothiazide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Losartan and Hydrochlorothiazide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Combining these types of blood pressure medicines can increase the risk of kidney damage and high potassium levels.
FDA Label Information
The VA NEPHRON trial enrolled 1448 patients with type 2 diabetes, elevated urinary-albumin-to-creatinine ratio, and decreased estimated glomerular filtration rate (GFR 30 to 89.9 ml/min), randomized them to lisinopril or placebo on a background of losartan therapy and followed them for a median of 2.2 years. Patients receiving the combination of losartan and lisinopril did not obtain any additional benefit compared to monotherapy for the combined endpoint of decline in GFR, end state renal disease, or death, but experienced an increased incidence of hyperkalemia and acute kidney injury...
Losartan Also Interacts With
- Aliskiren major
- Lithium moderate
- Fluconazole minor
- Glecaprevir/Pibrentasvir minor
- Hydrochlorothiazide/Lisinopril minor
Hydrochlorothiazide Also Interacts With
- Aliskiren major
- Hydrochlorothiazide/Triamterene major
- Lisinopril major
- Olmesartan moderate
- Spironolactone minor
Frequently Asked Questions
What SPL severity band is on file for Losartan + Hydrochlorothiazide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Hydrochlorothiazide has 31 labeled pairs on file vs Losartan's 10. In the minor band specifically: Losartan has 8 (also Fluconazole, Glecaprevir/Pibrentasvir, Hydrochlorothiazide, Hydrochlorothiazide/Losartan); Hydrochlorothiazide has 27 (also Spironolactone, Propranolol, Lithium, Amiloride).
What mechanism field is on file for Losartan and Hydrochlorothiazide?
Combining these types of blood pressure medicines can increase the risk of kidney damage and high potassium levels.
Hydrochlorothiazide carries more major-labeled pairs than Losartan
SPL source-record counts only. This page's band is minor · classes on file: Losartan (Angiotensin II Receptor Blocker (ARB)); Hydrochlorothiazide (Thiazide Diuretic).
Hydrochlorothiazide has 3 major-labeled pairs vs Losartan's 1. This page itself is in the minor band, not the major band.
1 major · 1 moderate · 8 minor · 10 total
- Other minor peers for Losartan
- Fluconazole
- Glecaprevir/Pibrentasvir
- Hydrochlorothiazide
- Hydrochlorothiazide/Losartan
3 major · 1 moderate · 27 minor · 31 total
- Other minor peers for Hydrochlorothiazide
- Spironolactone
- Propranolol
- Lithium
- Amiloride
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.