Losartan and Fluconazole Interaction
Drug interaction information between Losartan and Fluconazole.
Losartan and Fluconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Losartan and Fluconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluconazole prevents losartan from changing into its active form that helps lower blood pressure. This can make the blood pressure medicine work less effectively.
FDA Label Information
Losartan : Fluconazole inhibits the metabolism of losartan to its active metabolite (E-31 74) which is responsible for most of the angiotensin II-receptor antagonism which occurs during treatment with losartan.
Losartan Also Interacts With
- Aliskiren major
- Lithium moderate
- Glecaprevir/Pibrentasvir minor
- Hydrochlorothiazide minor
- Hydrochlorothiazide/Lisinopril minor
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Losartan + Fluconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Losartan's 10. In the minor band specifically: Losartan has 8 (also Glecaprevir/Pibrentasvir, Hydrochlorothiazide, Hydrochlorothiazide, Hydrochlorothiazide/Losartan); Fluconazole has 57 (also Amlodipine, Hydrochlorothiazide, Meloxicam, Ibuprofen).
What mechanism field is on file for Losartan and Fluconazole?
Fluconazole prevents losartan from changing into its active form that helps lower blood pressure. This can make the blood pressure medicine work less effectively.
Fluconazole carries more major-labeled pairs than Losartan
SPL source-record counts only. This page's band is minor · classes on file: Losartan (Angiotensin II Receptor Blocker (ARB)); Fluconazole (Azole Antifungal).
Fluconazole has 3 major-labeled pairs vs Losartan's 1. This page itself is in the minor band, not the major band.
1 major · 1 moderate · 8 minor · 10 total
- Other minor peers for Losartan
- Glecaprevir/Pibrentasvir
- Hydrochlorothiazide
- Hydrochlorothiazide
- Hydrochlorothiazide/Losartan
3 major · 7 moderate · 57 minor · 67 total
- Other minor peers for Fluconazole
- Amlodipine
- Hydrochlorothiazide
- Meloxicam
- Ibuprofen
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.