What the FDA labels say about taking them together
Fluconazole and losartan
Fluconazole's FDA label (Fluconazole) of April 2, 2026 names losartan in its drug interactions section, and losartan's label names fluconazole too. The losartan label: “Fluconazole, an inhibitor of cytochrome P450 2C9, decreased the AUC of the active metabolite by approximately 40%, but increased the AUC of losartan by approximately 70% following multiple doses.”
Check it at the source: the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.); the losartan FDA label on DailyMed (effective January 20, 2026, Organon LLC).
What does the fluconazole label say about losartan?
Fluconazole label (Mylan Pharmaceuticals Inc., April 2, 2026), drug interactionsLosartan Fluconazole inhibits the metabolism of losartan to its active metabolite (E-31 74) which is responsible for most of the angiotensin II-receptor antagonism which occurs during treatment with losartan.
Source: FDA drug label (Fluconazole, NDA020090), Mylan Pharmaceuticals Inc., effective April 2, 2026 (SPL set 737e0fac-a2d2-4053-a0d7-edbfb6248f69), via openFDA
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
What does the losartan label say about fluconazole?
Losartan label, drug interactionsFluconazole, an inhibitor of cytochrome P450 2C9, decreased the AUC of the active metabolite by approximately 40%, but increased the AUC of losartan by approximately 70% following multiple doses.
Source: FDA drug label (COZAAR), Organon LLC, effective January 20, 2026 (SPL set 9949448f-c3b9-44ee-94ed-c1aca8c90f39), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluconazole | Losartan | |
|---|---|---|
| Labeled for | Fungal infections, Urinary tract infections | High blood pressure, Chronic kidney disease, Stroke prevention |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.380 per tablet 200 mg tablet | $0.0327 per tablet 50 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once