Losartan and Fluconazole Interaction
Drug interaction information between Losartan and Fluconazole.
Losartan and Fluconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Losartan and Fluconazole. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Fluconazole prevents losartan from changing into its active form that helps lower blood pressure. This can make the blood pressure medicine work less effectively.
What To Do
Your doctor may need to monitor your blood pressure and adjust your treatment if it is not controlled.
FDA Label Information
Losartan : Fluconazole inhibits the metabolism of losartan to its active metabolite (E-31 74) which is responsible for most of the angiotensin II-receptor antagonism which occurs during treatment with losartan.
Losartan Also Interacts With
- Aliskiren major
- Lithium moderate
- Glecaprevir/Pibrentasvir minor
- Hydrochlorothiazide minor
- Hydrochlorothiazide/Lisinopril minor
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Frequently Asked Questions
Can I take Losartan and Fluconazole together?
This is a minor interaction. Your doctor may need to monitor your blood pressure and adjust your treatment if it is not controlled.
How serious is the interaction between Losartan and Fluconazole?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Losartan and Fluconazole interact?
Fluconazole prevents losartan from changing into its active form that helps lower blood pressure. This can make the blood pressure medicine work less effectively.
Understanding the Losartan and Fluconazole Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Losartan belongs to the Angiotensin II Receptor Blocker (ARB) class and Fluconazole belongs to the Azole Antifungal class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Fluconazole prevents losartan from changing into its active form that helps lower blood pressure. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Losartan has 10 total documented interactions on file in this dataset, and Fluconazole has 67. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor may need to monitor your blood pressure and adjust your treatment if it is not controlled. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Losartan or Fluconazole based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.