Hydrochlorothiazide/Losartan and Hydrochlorothiazide Interaction
Drug interaction information between Hydrochlorothiazide/Losartan and Hydrochlorothiazide.
Hydrochlorothiazide/Losartan and Hydrochlorothiazide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Hydrochlorothiazide/Losartan and Hydrochlorothiazide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Pain relievers like NSAIDs can stop blood pressure medicines and water pills from working as well as they should. Taking these together can also put extra stress on your kidneys.
FDA Label Information
Hydrochlorothiazide The administration of a non-steroidal anti-inflammatory agent including a selective COX-2 inhibitor can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. Monitor renal function periodically in patients receiving hydrochlorothiazide, losartan, and NSAID therapy. 7.5 The Use of Hydrochlorothiazide with Other Drugs When administered concurrently, the following drugs may interact with thiazide diuretics [see Clinical Pharmacology (12.3) ]: Antidiabetic drugs (oral agents and insulin) — dosage adjustment of the...
Hydrochlorothiazide/Losartan Also Interacts With
- Aliskiren major
- Lithium moderate
- Lisinopril minor
- Losartan minor
- Cholestyramine minor
Hydrochlorothiazide Also Interacts With
- Aliskiren major
- Hydrochlorothiazide/Triamterene major
- Lisinopril major
- Olmesartan moderate
- Losartan minor
Frequently Asked Questions
What SPL severity band is on file for Hydrochlorothiazide/Losartan + Hydrochlorothiazide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Hydrochlorothiazide has 31 labeled pairs on file vs Hydrochlorothiazide/Losartan's 7. In the minor band specifically: Hydrochlorothiazide/Losartan has 5 (also Lisinopril, Losartan, Cholestyramine, Colestipol); Hydrochlorothiazide has 27 (also Losartan, Spironolactone, Propranolol, Lithium).
What mechanism field is on file for Hydrochlorothiazide/Losartan and Hydrochlorothiazide?
Pain relievers like NSAIDs can stop blood pressure medicines and water pills from working as well as they should. Taking these together can also put extra stress on your kidneys.
Hydrochlorothiazide carries more major-labeled pairs than Hydrochlorothiazide/Losartan
SPL source-record counts only. This page's band is minor · classes on file: Hydrochlorothiazide/Losartan (Thiazide Diuretic / ARB Combination); Hydrochlorothiazide (Thiazide Diuretic).
Hydrochlorothiazide has 3 major-labeled pairs vs Hydrochlorothiazide/Losartan's 1. This page itself is in the minor band, not the major band.
1 major · 1 moderate · 5 minor · 7 total
- Other minor peers for Hydrochlorothiazide/Losartan
- Lisinopril
- Losartan
- Cholestyramine
- Colestipol
3 major · 1 moderate · 27 minor · 31 total
- Other minor peers for Hydrochlorothiazide
- Losartan
- Spironolactone
- Propranolol
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.