Losartan and Aliskiren Interaction
Drug interaction information between Losartan and Aliskiren.
Losartan and Aliskiren have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Losartan and Aliskiren. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these two drugs together can over-block the system that controls blood pressure, potentially causing fainting or kidney failure.
FDA Label Information
7.4 Dual Blockade of the Renin-Angiotensin System (RAS) Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, syncope, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. Do not coadminister aliskiren with losartan potassium in patients with diabetes. Avoid use of aliskiren with losartan potassium in patients with renal impairment (GFR <60 mL/min).
Losartan Also Interacts With
- Lithium moderate
- Fluconazole minor
- Glecaprevir/Pibrentasvir minor
- Hydrochlorothiazide minor
- Hydrochlorothiazide/Lisinopril minor
Aliskiren Also Interacts With
- Amlodipine/Benazepril major
- Amlodipine/Valsartan major
- Azilsartan major
- Benazepril major
- Candesartan major
Frequently Asked Questions
What SPL severity band is on file for Losartan + Aliskiren?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aliskiren has 28 labeled pairs on file vs Losartan's 10. In the major band specifically: Losartan has 1; Aliskiren has 22 (also Amlodipine/Benazepril, Amlodipine/Valsartan, Azilsartan, Benazepril).
What mechanism field is on file for Losartan and Aliskiren?
Taking these two drugs together can over-block the system that controls blood pressure, potentially causing fainting or kidney failure.
Aliskiren carries more major-labeled pairs than Losartan
SPL source-record counts only. This page's band is major · classes on file: Losartan (Angiotensin II Receptor Blocker (ARB)); Aliskiren (Direct Renin Inhibitor).
Aliskiren has 22 major-labeled pairs vs Losartan's 1.
1 major · 1 moderate · 8 minor · 10 total
Losartan has no other major-band peer in this dataset besides Aliskiren.
22 major · 3 moderate · 3 minor · 28 total
- Other major peers for Aliskiren
- Amlodipine/Benazepril
- Amlodipine/Valsartan
- Azilsartan
- Benazepril
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.