Hydrochlorothiazide/Losartan and Cholestyramine Interaction
Drug interaction information between Hydrochlorothiazide/Losartan and Cholestyramine.
Hydrochlorothiazide/Losartan and Cholestyramine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Hydrochlorothiazide/Losartan and Cholestyramine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This medicine acts like a magnet in your stomach and sticks to the water pill, which prevents your body from absorbing it. This can make your blood pressure medicine much less effective.
FDA Label Information
( 7.5 ) Cholestyramine and colestipol: Reduced absorption of thiazides. Cholestyramine and colestipol resins — Absorption of hydrochlorothiazide is impaired in the presence of anionic exchange resins. Single doses of either cholestyramine or colestipol resins bind the hydrochlorothiazide and reduce its absorption from the gastrointestinal tract by up to 85 and 43 percent, respectively.
Hydrochlorothiazide/Losartan Also Interacts With
- Aliskiren major
- Lithium moderate
- Lisinopril minor
- Losartan minor
- Hydrochlorothiazide minor
Cholestyramine Also Interacts With
- Naproxen moderate
- Olmesartan moderate
- Raloxifene moderate
- Propranolol minor
- Warfarin minor
Frequently Asked Questions
What SPL severity band is on file for Hydrochlorothiazide/Losartan + Cholestyramine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cholestyramine has 34 labeled pairs on file vs Hydrochlorothiazide/Losartan's 7. In the minor band specifically: Hydrochlorothiazide/Losartan has 5 (also Lisinopril, Losartan, Hydrochlorothiazide, Colestipol); Cholestyramine has 31 (also Propranolol, Warfarin, Tetracycline, Phenobarbital).
What mechanism field is on file for Hydrochlorothiazide/Losartan and Cholestyramine?
This medicine acts like a magnet in your stomach and sticks to the water pill, which prevents your body from absorbing it. This can make your blood pressure medicine much less effective.
Hydrochlorothiazide/Losartan carries more major-labeled pairs than Cholestyramine
SPL source-record counts only. This page's band is minor · classes on file: Hydrochlorothiazide/Losartan (Thiazide Diuretic / ARB Combination); Cholestyramine (Bile Acid Sequestrant).
Hydrochlorothiazide/Losartan has 1 major-labeled pair vs Cholestyramine's 0. This page itself is in the minor band, not the major band.
1 major · 1 moderate · 5 minor · 7 total
- Other minor peers for Hydrochlorothiazide/Losartan
- Lisinopril
- Losartan
- Hydrochlorothiazide
- Colestipol
0 major · 3 moderate · 31 minor · 34 total
- Other minor peers for Cholestyramine
- Propranolol
- Warfarin
- Tetracycline
- Phenobarbital
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.