Hydrochlorothiazide/Losartan and Lisinopril Interaction
Drug interaction information between Hydrochlorothiazide/Losartan and Lisinopril.
Hydrochlorothiazide/Losartan and Lisinopril have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Hydrochlorothiazide/Losartan and Lisinopril. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Combining these two similar types of blood pressure drugs does not offer extra protection for your heart or kidneys and increases the risk of side effects.
FDA Label Information
The Veterans Affairs Nephropathy in Diabetes (VA NEPHRON-D) trial enrolled 1448 patients with type 2 diabetes, elevated urinary-albumin-to-creatinine ratio, and decreased estimated glomerular filtration rate (GFR 30 to 89.9 mL/min), randomized them to lisinopril or placebo on a background of losartan therapy and followed them for a median of 2.2 years. Patients receiving the combination of losartan and lisinopril did not obtain any additional benefit compared to monotherapy for the combined endpoint of decline in GFR, end-stage renal disease, or death, but experienced an increased...
Hydrochlorothiazide/Losartan Also Interacts With
- Aliskiren major
- Lithium moderate
- Losartan minor
- Hydrochlorothiazide minor
- Cholestyramine minor
Lisinopril Also Interacts With
- Hydrochlorothiazide major
- Aliskiren major
- Losartan minor
- Spironolactone minor
- Propranolol minor
Frequently Asked Questions
What SPL severity band is on file for Hydrochlorothiazide/Losartan + Lisinopril?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lisinopril has 15 labeled pairs on file vs Hydrochlorothiazide/Losartan's 7. In the minor band specifically: Hydrochlorothiazide/Losartan has 5 (also Losartan, Hydrochlorothiazide, Cholestyramine, Colestipol); Lisinopril has 13 (also Losartan, Spironolactone, Propranolol, Lithium).
What mechanism field is on file for Hydrochlorothiazide/Losartan and Lisinopril?
Combining these two similar types of blood pressure drugs does not offer extra protection for your heart or kidneys and increases the risk of side effects.
Lisinopril carries more major-labeled pairs than Hydrochlorothiazide/Losartan
SPL source-record counts only. This page's band is minor · classes on file: Hydrochlorothiazide/Losartan (Thiazide Diuretic / ARB Combination); Lisinopril (ACE Inhibitor).
Lisinopril has 2 major-labeled pairs vs Hydrochlorothiazide/Losartan's 1. This page itself is in the minor band, not the major band.
1 major · 1 moderate · 5 minor · 7 total
- Other minor peers for Hydrochlorothiazide/Losartan
- Losartan
- Hydrochlorothiazide
- Cholestyramine
- Colestipol
2 major · 0 moderate · 13 minor · 15 total
- Other minor peers for Lisinopril
- Losartan
- Spironolactone
- Propranolol
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.