What the FDA labels say about taking them together
Lithium and losartan
Losartan's FDA label of January 20, 2026 names lithium in its drug interactions section; the lithium labels PlainMeds reads (4) do not name losartan. The losartan label: “Risk of lithium toxicity. NSAIDs: Increased risk of renal impairment and reduced diuretic, natriuretic, and antihypertensive effects. Dual Inhibition of the Renin-Angiotensin System:”
Check it at the source: the lithium FDA label on DailyMed (effective December 23, 2025, Glenmark Pharmaceuticals Inc., USA); the losartan FDA label on DailyMed (effective January 20, 2026, Organon LLC).
What does the lithium label say about losartan?
Lithium's label (effective December 23, 2025) and its 3 other brand-application labels do not name losartan in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lithium Carbonate), Glenmark Pharmaceuticals Inc., USA, effective December 23, 2025 (SPL set 63b3790f-a9b5-47f4-bae1-ddf8b43c13c1), via openFDA; the full label on DailyMed
What does the losartan label say about lithium?
Losartan label, drug interactionsRisk of lithium toxicity. ( 7.2 ) NSAIDs: Increased risk of renal impairment and reduced diuretic, natriuretic, and antihypertensive effects. ( 7.3 ) Dual Inhibition of the Renin-Angiotensin System:
Source: FDA drug label (COZAAR), Organon LLC, effective January 20, 2026 (SPL set 9949448f-c3b9-44ee-94ed-c1aca8c90f39), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lithium | Losartan | |
|---|---|---|
| Labeled for | Bipolar disorder | High blood pressure, Chronic kidney disease, Stroke prevention |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.104 per capsule 300 mg capsule | $0.0327 per tablet 50 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once