Losartan and Lithium Interaction
Drug interaction information between Losartan and Lithium.
Losartan and Lithium have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Losartan and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Losartan can make it harder for your body to get rid of lithium. This can cause lithium to build up to dangerous levels in your blood.
FDA Label Information
(7.1) • Lithium: Risk of lithium toxicity. 7.2 Lithium Increases in serum lithium concentrations and lithium toxicity have been reported during concomitant administration of lithium with angiotensin II receptor antagonists. Monitor serum lithium levels during concomitant use.
Losartan Also Interacts With
- Aliskiren major
- Fluconazole minor
- Glecaprevir/Pibrentasvir minor
- Hydrochlorothiazide minor
- Hydrochlorothiazide/Lisinopril minor
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Losartan + Lithium?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Losartan's 10. In the moderate band specifically: Losartan has 1; Lithium has 23 (also Amiloride, Amiodarone, Amlodipine/Valsartan, Azilsartan).
What mechanism field is on file for Losartan and Lithium?
Losartan can make it harder for your body to get rid of lithium. This can cause lithium to build up to dangerous levels in your blood.
Lithium carries more major-labeled pairs than Losartan
SPL source-record counts only. This page's band is moderate · classes on file: Losartan (Angiotensin II Receptor Blocker (ARB)); Lithium (Mood Stabilizer).
Lithium has 2 major-labeled pairs vs Losartan's 1. This page itself is in the moderate band, not the major band.
1 major · 1 moderate · 8 minor · 10 total
Losartan has no other moderate-band peer in this dataset besides Lithium.
2 major · 23 moderate · 65 minor · 90 total
- Other moderate peers for Lithium
- Amiloride
- Amiodarone
- Amlodipine/Valsartan
- Azilsartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.