Losartan and Glecaprevir/Pibrentasvir Interaction
Drug interaction information between Losartan and Glecaprevir/Pibrentasvir.
Losartan and Glecaprevir/Pibrentasvir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Losartan and Glecaprevir/Pibrentasvir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
There are no known significant interactions between these two medications.
FDA Label Information
7.5 Drugs with No Observed Clinically Significant Interactions with MAVYRET No dose adjustment is required when MAVYRET is coadministered with the following medications: abacavir, amlodipine, caffeine, dextromethorphan, dolutegravir, elvitegravir/ cobicistat, emtricitabine, ethinyl estradiol of 20 mcg or less, felodipine, lamivudine, lamotrigine, losartan, midazolam, norethindrone or other progestin-only contraceptives, omeprazole, raltegravir, rilpivirine, sofosbuvir, tacrolimus, tenofovir alafenamide, tenofovir disoproxil fumarate, tolbutamide, and valsartan.
Losartan Also Interacts With
- Aliskiren major
- Lithium moderate
- Fluconazole minor
- Hydrochlorothiazide minor
- Hydrochlorothiazide/Lisinopril minor
Glecaprevir/Pibrentasvir Also Interacts With
- Rifampin major
- Rosuvastatin major
- Rosuvastatin/Ezetimibe major
- Cyclosporine moderate
- Darunavir moderate
Frequently Asked Questions
What SPL severity band is on file for Losartan + Glecaprevir/Pibrentasvir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Glecaprevir/Pibrentasvir has 38 labeled pairs on file vs Losartan's 10. In the minor band specifically: Losartan has 8 (also Fluconazole, Hydrochlorothiazide, Hydrochlorothiazide, Hydrochlorothiazide/Losartan); Glecaprevir/Pibrentasvir has 26 (also Atorvastatin, Amlodipine, Omeprazole, Simvastatin).
What mechanism field is on file for Losartan and Glecaprevir/Pibrentasvir?
There are no known significant interactions between these two medications.
Glecaprevir/Pibrentasvir carries more major-labeled pairs than Losartan
SPL source-record counts only. This page's band is minor · classes on file: Losartan (Angiotensin II Receptor Blocker (ARB)); Glecaprevir/Pibrentasvir (NS3/4A/NS5A Inhibitor (HCV)).
Glecaprevir/Pibrentasvir has 3 major-labeled pairs vs Losartan's 1. This page itself is in the minor band, not the major band.
1 major · 1 moderate · 8 minor · 10 total
- Other minor peers for Losartan
- Fluconazole
- Hydrochlorothiazide
- Hydrochlorothiazide
- Hydrochlorothiazide/Losartan
3 major · 9 moderate · 26 minor · 38 total
- Other minor peers for Glecaprevir/Pibrentasvir
- Atorvastatin
- Amlodipine
- Omeprazole
- Simvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.