Hydrochlorothiazide/Losartan and Lithium Interaction
Drug interaction information between Hydrochlorothiazide/Losartan and Lithium.
Hydrochlorothiazide/Losartan and Lithium have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Hydrochlorothiazide/Losartan and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These blood pressure medications can cause the amount of lithium in your body to rise to dangerous levels. This happens because the drugs change how your kidneys get rid of lithium.
FDA Label Information
( 7.1 ) Lithium: Risk of lithium toxicity. 7.2 Lithium Increases in serum lithium concentrations and lithium toxicity have been reported with concomitant use of angiotensin II receptor antagonists or thiazide diuretics. Monitor lithium levels in patients receiving HYZAAR and lithium.
Hydrochlorothiazide/Losartan Also Interacts With
- Aliskiren major
- Lisinopril minor
- Losartan minor
- Hydrochlorothiazide minor
- Cholestyramine minor
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Hydrochlorothiazide/Losartan + Lithium?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Hydrochlorothiazide/Losartan's 7. In the moderate band specifically: Hydrochlorothiazide/Losartan has 1; Lithium has 23 (also Amiloride, Amiodarone, Amlodipine/Valsartan, Azilsartan).
What mechanism field is on file for Hydrochlorothiazide/Losartan and Lithium?
These blood pressure medications can cause the amount of lithium in your body to rise to dangerous levels. This happens because the drugs change how your kidneys get rid of lithium.
Lithium carries more major-labeled pairs than Hydrochlorothiazide/Losartan
SPL source-record counts only. This page's band is moderate · classes on file: Hydrochlorothiazide/Losartan (Thiazide Diuretic / ARB Combination); Lithium (Mood Stabilizer).
Lithium has 2 major-labeled pairs vs Hydrochlorothiazide/Losartan's 1. This page itself is in the moderate band, not the major band.
1 major · 1 moderate · 5 minor · 7 total
Hydrochlorothiazide/Losartan has no other moderate-band peer in this dataset besides Lithium.
2 major · 23 moderate · 65 minor · 90 total
- Other moderate peers for Lithium
- Amiloride
- Amiodarone
- Amlodipine/Valsartan
- Azilsartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.