aripiprazole vs lorazepam
Side-by-side comparison of aripiprazole and lorazepam. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Benzodiazepines (e.g., lorazepam) The intensity of sedation was greater with the combination of oral aripiprazole and lorazepam as compared to that observed with aripiprazole alone. The orthostatic hypotension observed was greater with the combination as compared to that observed with lorazepam alone [see Warnings and Precautions (5.8)] Monitor sedation and blood pressure. 7.2 Drugs Having No Clinically Important Interactions with Aripiprazole Based on pharmacokinetic studies, no dosage adjustment of aripiprazole is required when administered concomitantly with famotidine, valproate,...
Recommendation: Your healthcare provider should monitor you closely for extreme sleepiness and changes in your blood pressure.
Abilify
Ativan
Aripiprazole (Abilify) is a medicine used to treat certain mental disorders and mood problems. It can help to improve your mood, thinking, and behavior.
Lorazepam is a medicine that can help with anxiety. It belongs to a class of drugs called benzodiazepines, which slow down activity in the brain.
Aripiprazole is used to treat schizophrenia in adults and teens. It also treats irritability in children with autism. Additionally, it can treat Tourette's disorder.
Lorazepam is used to manage anxiety disorders. It can also provide short-term relief from anxiety symptoms or anxiety linked to depression. However, it is not for the stress of everyday life. Talk to your doctor regularly to see if you still need this medicine.
Aripiprazole works by affecting the levels of certain chemicals in the brain. These chemicals, like dopamine and serotonin, can affect mood and behavior. By balancing these chemicals, aripiprazole helps to reduce symptoms of mental health conditions.
Lorazepam works by affecting certain chemicals in your brain. It enhances the effects of a natural brain chemical called GABA. This helps to calm your nerves and reduce anxiety.
- • Nausea
- • Vomiting
- • Constipation
- • Headache
- • Dizziness
- • Feeling sleepy or drowsy
- • Dizziness
- Gaining weight 7,698
- Feeling worried or nervous 4,995
- Feeling tired 4,188
- Thinking about suicide 3,991
- Feeling sad or hopeless 3,952
- Tiredness 13,458
- Feeling sick to your stomach 13,333
- Loose stools 10,352
- Difficulty breathing 9,234
- Feeling worried or nervous 8,840
Aripiprazole may increase the risk of death in elderly patients who have psychosis related to dementia. It is not approved for this use. Antidepressants may increase the risk of suicidal thoughts and behaviors in children, teens, and young adults. Watch closely for worsening mood or suicidal thoughts.
Taking lorazepam with opioid medicines can cause very serious problems, including slowed or shallow breathing, coma, and death. Only take them together if there are no other options. Lorazepam can be habit-forming, leading to abuse, misuse, and addiction, which can result in overdose or death. Using lorazepam for a long time can cause you to become dependent on it. Stopping it suddenly can cause dangerous withdrawal symptoms. Your doctor will slowly lower your dose to prevent withdrawal.
If you are pregnant or plan to become pregnant, talk to your doctor. Aripiprazole may cause withdrawal symptoms or other problems in newborns if taken during the third trimester. There is a pregnancy registry for women who take aripiprazole during pregnancy.
Lorazepam may harm an unborn baby. Talk to your doctor if you are pregnant, plan to become pregnant, or are breastfeeding while taking this medicine. It can pass into breast milk and affect the baby.
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How to Read This aripiprazole vs lorazepam Comparison
aripiprazole is classified in the Atypical Antipsychotic drug class, while lorazepam sits within the Benzodiazepine class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, aripiprazole has 24,824 submissions while lorazepam has 55,217. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to both drugs can cause sleepiness and low blood pressure, and taking them together makes these side effects much stronger.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between aripiprazole and lorazepam - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.