Linezolid and Vortioxetine Interaction
Drug interaction information between Linezolid and Vortioxetine.
Linezolid and Vortioxetine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Linezolid and Vortioxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these drugs increase the amount of a chemical called serotonin in your brain, and having too much can be dangerous.
FDA Label Information
In a patient who is being treated with linezolid or intravenous methylene blue. [see Dosage and Administration (2.4) , Contraindications (4) , Warnings and Precautions (5.2) ] Examples selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue Other Serotonergic Drugs Clinical Impact Concomitant use of TRINTELLIX with other serotonergic drugs increases the risk of serotonin syndrome.
Linezolid Also Interacts With
- Citalopram major
- Escitalopram major
- Mirtazapine major
- Paroxetine major
- Safinamide major
Vortioxetine Also Interacts With
- Carbamazepine moderate
- Rifampin moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Selegiline moderate
Frequently Asked Questions
What SPL severity band is on file for Linezolid + Vortioxetine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Linezolid has 29 labeled pairs on file vs Vortioxetine's 18. In the moderate band specifically: Linezolid has 3 (also Desvenlafaxine, Levomilnacipran); Vortioxetine has 7 (also Carbamazepine, Rifampin, Phenelzine, Tranylcypromine).
What mechanism field is on file for Linezolid and Vortioxetine?
Both of these drugs increase the amount of a chemical called serotonin in your brain, and having too much can be dangerous.
Linezolid carries more major-labeled pairs than Vortioxetine
SPL source-record counts only. This page's band is moderate · classes on file: Linezolid (Oxazolidinone Antibiotic); Vortioxetine (Serotonin Modulator).
Linezolid has 8 major-labeled pairs vs Vortioxetine's 0. This page itself is in the moderate band, not the major band.
8 major · 3 moderate · 18 minor · 29 total
- Other moderate peers for Linezolid
- Desvenlafaxine
- Levomilnacipran
0 major · 7 moderate · 11 minor · 18 total
- Other moderate peers for Vortioxetine
- Carbamazepine
- Rifampin
- Phenelzine
- Tranylcypromine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.