Linezolid and Levomilnacipran Interaction
Drug interaction information between Linezolid and Levomilnacipran.
Linezolid and Levomilnacipran have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Linezolid and Levomilnacipran. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medications increase the levels of a brain chemical called serotonin. If levels get too high, it can lead to a serious and potentially life-threatening reaction.
FDA Label Information
Within 14 days of stopping an MAOI intended to treat psychiatric disorders In a patient who is being treated with linezolid or intravenous methylene blue [see Dosage and Administration ( 2.5 , 2.6 ), Contraindications ( 4 ), and Warnings and Precautions ( 5.2 )] . Examples: selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue Other Serotonergic Drugs Clinical Impact: Concomitant use of FETZIMA with other serotonergic drugs increases the risk of serotonin syndrome.
Linezolid Also Interacts With
- Citalopram major
- Escitalopram major
- Mirtazapine major
- Paroxetine major
- Safinamide major
Levomilnacipran Also Interacts With
- Phenelzine moderate
- Tranylcypromine moderate
- Selegiline moderate
- Buspirone minor
- Aspirin minor
Frequently Asked Questions
What SPL severity band is on file for Linezolid + Levomilnacipran?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Linezolid has 29 labeled pairs on file vs Levomilnacipran's 11. In the moderate band specifically: Linezolid has 3 (also Desvenlafaxine, Vortioxetine); Levomilnacipran has 4 (also Phenelzine, Tranylcypromine, Selegiline).
What mechanism field is on file for Linezolid and Levomilnacipran?
Both of these medications increase the levels of a brain chemical called serotonin. If levels get too high, it can lead to a serious and potentially life-threatening reaction.
Linezolid carries more major-labeled pairs than Levomilnacipran
SPL source-record counts only. This page's band is moderate · classes on file: Linezolid (Oxazolidinone Antibiotic); Levomilnacipran (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)).
Linezolid has 8 major-labeled pairs vs Levomilnacipran's 0. This page itself is in the moderate band, not the major band.
8 major · 3 moderate · 18 minor · 29 total
- Other moderate peers for Linezolid
- Desvenlafaxine
- Vortioxetine
0 major · 4 moderate · 7 minor · 11 total
- Other moderate peers for Levomilnacipran
- Phenelzine
- Tranylcypromine
- Selegiline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.