Codeine and Cyclobenzaprine Interaction
Drug interaction information between Codeine and Cyclobenzaprine.
Codeine and Cyclobenzaprine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Codeine and Cyclobenzaprine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these two drugs together can raise serotonin levels in your brain to an unsafe level. This increases the risk of a serious reaction called serotonin syndrome.
FDA Label Information
Examples of these drugs include, selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, drugs that affect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), and monoamine oxidase (MAO) inhibitors (used to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue) (see PRECAUTIONS; Information for Patients/Caregivers ).
Codeine Also Interacts With
- Bupropion minor
- Fluoxetine minor
- Trazodone minor
- Tramadol minor
- Oxycodone minor
Cyclobenzaprine Also Interacts With
- Clozapine moderate
- Tapentadol moderate
- Tranylcypromine moderate
- Acetaminophen/Oxycodone minor
- Buprenorphine minor
Frequently Asked Questions
What SPL severity band is on file for Codeine + Cyclobenzaprine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Codeine has 27 labeled pairs on file vs Cyclobenzaprine's 17. In the minor band specifically: Codeine has 27 (also Bupropion, Fluoxetine, Trazodone, Tramadol); Cyclobenzaprine has 14 (also Acetaminophen/Oxycodone, Buprenorphine, Buprenorphine/Naloxone, Buprenorphine).
What mechanism field is on file for Codeine and Cyclobenzaprine?
Taking these two drugs together can raise serotonin levels in your brain to an unsafe level. This increases the risk of a serious reaction called serotonin syndrome.
Codeine's labeled portfolio outnumbers Cyclobenzaprine
SPL source-record counts only. This page's band is minor · classes on file: Codeine (Opioid Analgesic); Cyclobenzaprine (Muscle Relaxant).
0 major · 0 moderate · 27 minor · 27 total
- Other minor peers for Codeine
- Bupropion
- Fluoxetine
- Trazodone
- Tramadol
0 major · 3 moderate · 14 minor · 17 total
- Other minor peers for Cyclobenzaprine
- Acetaminophen/Oxycodone
- Buprenorphine
- Buprenorphine/Naloxone
- Buprenorphine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.