Codeine and Bupropion Interaction
Drug interaction information between Codeine and Bupropion.
Codeine and Bupropion have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Codeine and Bupropion. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Bupropion blocks the body from changing codeine into morphine, which is the active part that relieves pain. This can make the medicine less effective or cause withdrawal symptoms.
FDA Label Information
The concomitant use of acetaminophen and codeine phosphate tablets and CYP2D6 inhibitors (e.g., paroxetine, fluoxetine, bupropion, quinidine) can increase the plasma concentration of codeine, but can decrease the plasma concentration of active metabolite morphine, which could result in reduced analgesic efficacy or symptoms of opioid withdrawal, particularly when an inhibitor is added after a stable dose of acetaminophen and codeine phosphate tablets is achieved (see CLINICAL PHARMACOLOGY ).
Codeine Also Interacts With
- Fluoxetine minor
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
- Oxycodone minor
Bupropion Also Interacts With
- Tranylcypromine major
- Theophylline moderate
- Isavuconazonium moderate
- Metoprolol minor
- Sertraline minor
Frequently Asked Questions
What SPL severity band is on file for Codeine + Bupropion?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Bupropion has 35 labeled pairs on file vs Codeine's 27. In the minor band specifically: Codeine has 27 (also Fluoxetine, Trazodone, Tramadol, Cyclobenzaprine); Bupropion has 32 (also Metoprolol, Sertraline, Fluoxetine, Clopidogrel).
What mechanism field is on file for Codeine and Bupropion?
Bupropion blocks the body from changing codeine into morphine, which is the active part that relieves pain. This can make the medicine less effective or cause withdrawal symptoms.
Bupropion carries more major-labeled pairs than Codeine
SPL source-record counts only. This page's band is minor · classes on file: Codeine (Opioid Analgesic); Bupropion (Norepinephrine-Dopamine Reuptake Inhibitor (NDRI)).
Bupropion has 1 major-labeled pair vs Codeine's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 27 minor · 27 total
- Other minor peers for Codeine
- Fluoxetine
- Trazodone
- Tramadol
- Cyclobenzaprine
1 major · 2 moderate · 32 minor · 35 total
- Other minor peers for Bupropion
- Metoprolol
- Sertraline
- Fluoxetine
- Clopidogrel
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.