What the FDA labels say about taking them together
Bupropion and codeine
Codeine's FDA label of December 22, 2025 names bupropion in its drug interactions section; the bupropion labels PlainMeds reads (4) do not name codeine. The codeine label: “Codeine is metabolized by CYP2D6 to form morphine. The concomitant use of Codeine Sulfate Tablets and CYP2D6 inhibitors can increase the plasma concentration of codeine, but can decrease the plasma concentration of …”
Check it at the source: the bupropion FDA label on DailyMed (effective June 21, 2024); the codeine FDA label on DailyMed (effective December 22, 2025, Hikma Pharmaceuticals USA Inc.).
What does the bupropion label say about codeine?
Bupropion's label (effective June 21, 2024) and its 3 other brand-application labels do not name codeine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (BUPROPION HYDROCHLORIDE), Epic Pharma LLC, effective June 21, 2024 (SPL set 9fb44e96-6160-4a4a-90cb-91764c0dcd89), via openFDA; the full label on DailyMed
What does the codeine label say about bupropion?
Codeine label, drug interactionsRifampin, carbamazepine, phenytoin Inhibitors of CYP2D6 Clinical Impact: Codeine is metabolized by CYP2D6 to form morphine. The concomitant use of Codeine Sulfate Tablets and CYP2D6 inhibitors can increase the plasma concentration of codeine, but can decrease the plasma concentration of active metabolite morphine, which could result in reduced analgesic efficacy or symptoms of opioid withdrawal … frequent intervals for signs and symptoms of respiratory depression or sedation. Paroxetine, fluoxetine, bupropion, quinidine.
Source: FDA drug label (Codeine sulfate), Hikma Pharmaceuticals USA Inc., effective December 22, 2025 (SPL set 010905f9-3bcb-4b50-9fe8-a3ad0010f14c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bupropion | Codeine | |
|---|---|---|
| Labeled for | Depression, Quitting smoking | Pain |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0785 per tablet 150 mg tablet | $0.726 per tablet 30 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once