Zinc Sulfate and Baloxavir Marboxil Interaction

Drug interaction information between Zinc Sulfate and Baloxavir Marboxil.

Zinc Sulfate and Baloxavir Marboxil have a documented moderate interaction in FDA labeling.

FDA drug labeling documents a moderate-severity interaction between Zinc Sulfate and Baloxavir Marboxil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.

Drug A

Zinc Sulfate

Mineral Supplement

Drug B

Baloxavir Marboxil

Endonuclease Inhibitor (Antiviral)

How They Interact

Zinc can bind to this medicine in your stomach and prevent it from being absorbed into your body. This makes the medicine less effective at treating the flu.

FDA Label Information

7 DRUG INTERACTIONS Avoid coadministration of XOFLUZA with dairy products, calcium-fortified beverages, polyvalent cation-containing laxatives, antacids, or oral supplements (e.g., calcium, iron, magnesium, selenium, or zinc). Avoid coadministration of XOFLUZA with dairy products, calcium-fortified beverages, polyvalent cation-containing laxatives, antacids, or oral supplements (e.g., calcium, iron, magnesium, selenium, or zinc).

Baloxavir Marboxil Also Interacts With

View all Baloxavir Marboxil interactions →

Frequently Asked Questions

What SPL severity band is on file for Zinc Sulfate + Baloxavir Marboxil?

Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.

Which drug in this pair has the larger labeled-interaction portfolio?

Zinc Sulfate has 5 labeled pairs on file vs Baloxavir Marboxil's 2. In the moderate band specifically: Zinc Sulfate has 1; Baloxavir Marboxil has 2 (also Selenium).

What mechanism field is on file for Zinc Sulfate and Baloxavir Marboxil?

Zinc can bind to this medicine in your stomach and prevent it from being absorbed into your body. This makes the medicine less effective at treating the flu.

Zinc Sulfate's labeled portfolio outnumbers Baloxavir Marboxil

SPL source-record counts only. This page's band is moderate · classes on file: Zinc Sulfate (Mineral Supplement); Baloxavir Marboxil (Endonuclease Inhibitor (Antiviral)).

Zinc Sulfate

0 major · 1 moderate · 4 minor · 5 total

Zinc Sulfate has no other moderate-band peer in this dataset besides Baloxavir Marboxil.

Baloxavir Marboxil

0 major · 2 moderate · 0 minor · 2 total

  • Other moderate peers for Baloxavir Marboxil
  • Selenium

Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.