Probenecid and Cefuroxime Interaction
Drug interaction information between Probenecid and Cefuroxime.
Probenecid and Cefuroxime have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Probenecid and Cefuroxime. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Probenecid slows down the kidneys from removing the antibiotic from your blood. This leads to higher levels of the antibiotic in your body.
FDA Label Information
( 7.1 ) Coadministration with probenecid increases systemic exposure to cefuroxime axetil and is therefore not recommended. 7.2 Probenecid Concomitant administration of probenecid with cefuroxime axetil tablets increases serum concentrations of cefuroxime [see Clinical Pharmacology ( 12.3 )]. Coadministration of probenecid with cefuroxime axetil is not recommended.
Probenecid Also Interacts With
- Ketorolac major
- Levofloxacin major
- Amoxicillin moderate
- Amoxicillin/Clavulanate moderate
- Ceftazidime/Avibactam moderate
Frequently Asked Questions
What SPL severity band is on file for Probenecid + Cefuroxime?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Probenecid has 37 labeled pairs on file vs Cefuroxime's 1. In the moderate band specifically: Probenecid has 12 (also Amoxicillin, Amoxicillin/Clavulanate, Ceftazidime/Avibactam, Cephalexin); Cefuroxime has 1.
What mechanism field is on file for Probenecid and Cefuroxime?
Probenecid slows down the kidneys from removing the antibiotic from your blood. This leads to higher levels of the antibiotic in your body.
Probenecid carries more major-labeled pairs than Cefuroxime
SPL source-record counts only. This page's band is moderate · classes on file: Probenecid (Uricosuric Agent); Cefuroxime (Second-Generation Cephalosporin).
Probenecid has 2 major-labeled pairs vs Cefuroxime's 0. This page itself is in the moderate band, not the major band.
2 major · 12 moderate · 23 minor · 37 total
- Other moderate peers for Probenecid
- Amoxicillin
- Amoxicillin/Clavulanate
- Ceftazidime/Avibactam
- Cephalexin
0 major · 1 moderate · 0 minor · 1 total
Cefuroxime has no other moderate-band peer in this dataset besides Probenecid.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.