levofloxacin vs probenecid
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Side-by-side comparison of levofloxacin and probenecid. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
7.8 Probenecid and Cimetidine No significant effect of probenecid or cimetidine on the Cmax of levofloxacin was observed in a clinical study involving healthy volunteers. The AUC and t 1/2 of levofloxacin were higher while CL/F and CLR were lower during concomitant treatment of levofloxacin with probenecid or cimetidine compared to levofloxacin alone. However, these changes do not warrant dosage adjustment for levofloxacin when probenecid or cimetidine is co-administered.
Levaquin
Benemid
Levofloxacin is an antibiotic that fights bacteria in your body. It is used to treat different types of infections.
No summary available.
Levofloxacin treats infections like pneumonia, skin infections, prostate infections, and urinary tract infections. It can also treat anthrax after exposure and plague. This medicine should only be used for certain infections when other options won't work.
Information not available.
Levofloxacin belongs to a class of drugs called fluoroquinolones. It works by stopping bacteria from multiplying. This helps your body fight off the infection.
Information not available.
- • Nausea
- • Headache
- • Diarrhea
- • Trouble sleeping
- • Constipation
- • Diarrhea
- • Nausea
- • Yeast infection of the vagina
- • Headache
- • Vomiting
- Dyspnoea 2,950
- Pneumonia 2,863
- Nausea 2,790
- Pyrexia 2,723
- Fatigue 2,659
- Diarrhoea 76
- Dyspnoea 52
- Adenovirus Infection 47
- Asthenia 47
- Fatigue 46
This drug has serious warnings. Levofloxacin can cause tendon problems, nerve damage, and central nervous system effects. It can also make muscle weakness worse if you have myasthenia gravis. If you have any of these side effects, stop taking the medicine and call your doctor right away. Only use this medicine if you have no other treatment options for uncomplicated urinary tract infections, bronchitis, or sinusitis.
No specific warnings noted.
Tell your doctor if you are pregnant or plan to become pregnant. Levofloxacin should only be used during pregnancy if the benefit outweighs the risk to the baby. It may pass into breast milk, so talk to your doctor about breastfeeding.
No pregnancy information available.
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How to Read This levofloxacin vs probenecid Comparison
levofloxacin is classified in the Fluoroquinolone Antibiotic drug class, while probenecid sits within the Uricosuric Agent class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, levofloxacin has 13,985 submissions while probenecid has 268. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to probenecid slows down the kidneys' ability to remove levofloxacin, which keeps the antibiotic in your system for a longer time.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for levofloxacin or probenecid.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.