atorvastatin vs ledipasvir/sofosbuvir
Side-by-side comparison of atorvastatin and ledipasvir/sofosbuvir. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
atorvastatin ↑ atorvastatin Coadministration of HARVONI with atorvastatin may be associated with increased risk of myopathy, including rhabdomyolysis.
Recommendation: Your doctor should monitor you for muscle pain or consider changing your medication.
Lipitor
Harvoni
Atorvastatin is a drug that lowers cholesterol and reduces the risk of heart problems and stroke. It belongs to a class of drugs called statins.
Harvoni is a medicine that contains ledipasvir and sofosbuvir. It is used to treat chronic hepatitis C virus (HCV) infection in adults and children 3 years and older.
Atorvastatin is used to lower bad cholesterol (LDL) and triglycerides in your blood. It can help prevent heart attacks, strokes, and the need for heart procedures in adults with heart disease or risk factors for it. It is also used in children 10 years and older with certain inherited cholesterol problems.
Harvoni treats chronic Hepatitis C virus (HCV) genotypes 1, 4, 5, or 6. It can be used if you don't have cirrhosis or if you have compensated cirrhosis. If you have genotype 1 with decompensated cirrhosis or are a liver transplant recipient with genotype 1 or 4, you will take Harvoni with another medicine called ribavirin.
Atorvastatin works by blocking a substance your body needs to make cholesterol. This helps to lower the amount of cholesterol in your blood. Lowering cholesterol can help prevent heart disease.
Harvoni contains two medicines that stop the hepatitis C virus from multiplying in your body. Ledipasvir blocks a protein called NS5A. Sofosbuvir blocks another protein called NS5B.
- • Common cold symptoms
- • Joint pain
- • Diarrhea
- • Pain in arms or legs
- • Urinary tract infection
- • Feeling tired
- • Headache
- • Feeling weak
- • Nausea
- Tiredness 13,809
- Feeling sick to your stomach 12,421
- Type 2 diabetes 11,243
- Diarrhea 11,034
- Difficulty breathing 11,029
- Feeling tired 4,130
- Headache 3,706
- Nausea 1,240
- Diarrhea 913
- Hepatitis C 883
Atorvastatin can cause muscle problems, including muscle pain, tenderness, or weakness. In rare cases, this can lead to serious kidney damage. Tell your doctor right away if you have unexplained muscle pain, tenderness, or weakness, especially if you also have a fever or feel sick. Atorvastatin can also cause liver problems. Your doctor may do blood tests to check your liver before you start taking atorvastatin and while you are taking it.
Harvoni can cause Hepatitis B to become active again if you have had it in the past. This can cause serious liver problems, including liver failure and death. Your doctor will test you for Hepatitis B before you start Harvoni and monitor you during and after treatment.
Atorvastatin can harm an unborn baby. You should not take atorvastatin if you are pregnant or planning to become pregnant. It is also not recommended to breastfeed while taking atorvastatin.
If you are pregnant or plan to become pregnant, talk to your doctor before taking Harvoni. If Harvoni is taken with ribavirin, it is unsafe during pregnancy. Talk to your doctor if you are breastfeeding or plan to breastfeed.
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How to Read This atorvastatin vs ledipasvir/sofosbuvir Comparison
atorvastatin is classified in the HMG-CoA Reductase Inhibitor (Statin) drug class, while ledipasvir/sofosbuvir sits within the NS5A/NS5B Inhibitor (HCV) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, atorvastatin has 59,536 submissions while ledipasvir/sofosbuvir has 10,872. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to harvoni can increase the amount of atorvastatin in your system, which may lead to severe muscle problems.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between atorvastatin and ledipasvir/sofosbuvir - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.