Ivabradine and Itraconazole Interaction
Drug interaction information between Ivabradine and Itraconazole.
Ivabradine and Itraconazole have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Ivabradine and Itraconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole stops your body from processing ivabradine, which can lead to a risky buildup of the heart medication.
FDA Label Information
Cardiovascular Drugs, Miscellaneous Ivabradine Ranolazine Contraindicated during and 2 weeks after itraconazole treatment.
Ivabradine Also Interacts With
- Darunavir major
- Nirmatrelvir/Ritonavir major
- Voriconazole major
- Digoxin moderate
- Diltiazem moderate
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Ivabradine + Itraconazole?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Ivabradine's 10. In the major band specifically: Ivabradine has 4 (also Darunavir, Nirmatrelvir/Ritonavir, Voriconazole); Itraconazole has 19 (also Isavuconazonium, Lurasidone, Pimozide, Methadone).
What mechanism field is on file for Ivabradine and Itraconazole?
Itraconazole stops your body from processing ivabradine, which can lead to a risky buildup of the heart medication.
Itraconazole carries more major-labeled pairs than Ivabradine
SPL source-record counts only. This page's band is major · classes on file: Ivabradine (HCN Channel Blocker); Itraconazole (Azole Antifungal).
Itraconazole has 19 major-labeled pairs vs Ivabradine's 4.
4 major · 2 moderate · 4 minor · 10 total
- Other major peers for Ivabradine
- Darunavir
- Nirmatrelvir/Ritonavir
- Voriconazole
19 major · 20 moderate · 77 minor · 116 total
- Other major peers for Itraconazole
- Isavuconazonium
- Lurasidone
- Pimozide
- Methadone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.