itraconazole vs ivabradine
Side-by-side comparison of itraconazole and ivabradine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
Cardiovascular Drugs, Miscellaneous Ivabradine Ranolazine Contraindicated during and 2 weeks after itraconazole treatment.
Recommendation: Avoid using these two drugs at the same time or within two weeks of finishing your itraconazole prescription.
Sporanox
Corlanor
Itraconazole capsules are an antifungal medicine. They treat fungal infections in your body.
Ivabradine (Corlanor) is a medicine that helps lower the risk of needing to go to the hospital for worsening heart failure. It works by slowing down your heart rate.
Itraconazole treats fungal infections like blastomycosis, histoplasmosis, and aspergillosis. It can help both people with healthy immune systems and those with weakened immune systems. It also treats onychomycosis, a fungal infection of the toenails or fingernails.
Ivabradine is used to lower the chance of hospitalization if your heart failure gets worse. It is for adults who have stable, long-term heart failure and a weak heart (left ventricular ejection fraction ≤ 35%). You must also have a resting heart rate of 70 beats per minute or higher and are either taking the highest dose of beta-blockers you can handle or cannot take beta-blockers at all.
Itraconazole stops fungi from growing. It does this by interfering with the production of a substance fungi need to build their cell membranes. This eventually kills the fungus and clears the infection.
Ivabradine works by blocking certain channels in your heart called HCN channels. These channels control your heart's natural pacemaker. By blocking these channels, ivabradine slows down your heart rate.
- • Nausea
- • Rash
- • Headache
- • Slow heart rate
- • High blood pressure
- • Irregular heartbeat (atrial fibrillation)
- • Seeing bright flashes of light
- Interaction with another medicine 1,118
- Fever 570
- Difficulty breathing 472
- Lung infection 462
- Feeling sick to your stomach 446
- Shortness of breath 459
- Low blood pressure 413
- Feeling lightheaded or unsteady 350
- Heart failure 324
- Feeling very tired 317
Itraconazole can cause congestive heart failure. You should not take this medicine if you have heart problems. Itraconazole can also interact with many other medicines. Some of these interactions can be dangerous or even fatal. Check with your doctor about all the medicines you take.
Ivabradine can harm an unborn baby. If you are a woman who could get pregnant, use effective birth control while taking this medicine. This medicine can also cause a very slow heart rate. Your doctor will monitor your heart rate and adjust your dose as needed.
You should not take itraconazole if you are pregnant or plan to become pregnant. It can harm your unborn baby. Talk to your doctor about safe alternatives.
Ivabradine can cause harm to an unborn baby. Do not take this medicine if you are pregnant or planning to become pregnant. It is not recommended to breastfeed while taking ivabradine.
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How to Read This itraconazole vs ivabradine Comparison
itraconazole is classified in the Azole Antifungal drug class, while ivabradine sits within the HCN Channel Blocker class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, itraconazole has 3,068 submissions while ivabradine has 1,863. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to itraconazole stops your body from processing ivabradine, which can lead to a risky buildup of the heart medication.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between itraconazole and ivabradine - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.