Ivabradine and Nirmatrelvir/Ritonavir Interaction
Drug interaction information between Ivabradine and Nirmatrelvir/Ritonavir.
Ivabradine and Nirmatrelvir/Ritonavir have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Ivabradine and Nirmatrelvir/Ritonavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ritonavir blocks the breakdown of ivabradine, which makes the drug build up in your body. This can cause your heart to beat too slowly or skip beats.
FDA Label Information
ivabradine ↑ ivabradine Co-administration with ivabradine is contraindicated due to potential for bradycardia or conduction disturbances [see Contraindications (4) ] .
Ivabradine Also Interacts With
- Darunavir major
- Itraconazole major
- Voriconazole major
- Digoxin moderate
- Diltiazem moderate
Nirmatrelvir/Ritonavir Also Interacts With
- Simvastatin major
- Lovastatin major
- Sildenafil major
- Carbamazepine major
- Rifampin major
Frequently Asked Questions
What SPL severity band is on file for Ivabradine + Nirmatrelvir/Ritonavir?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nirmatrelvir/Ritonavir has 86 labeled pairs on file vs Ivabradine's 10. In the major band specifically: Ivabradine has 4 (also Darunavir, Itraconazole, Voriconazole); Nirmatrelvir/Ritonavir has 23 (also Simvastatin, Lovastatin, Sildenafil, Carbamazepine).
What mechanism field is on file for Ivabradine and Nirmatrelvir/Ritonavir?
Ritonavir blocks the breakdown of ivabradine, which makes the drug build up in your body. This can cause your heart to beat too slowly or skip beats.
Nirmatrelvir/Ritonavir carries more major-labeled pairs than Ivabradine
SPL source-record counts only. This page's band is major · classes on file: Ivabradine (HCN Channel Blocker); Nirmatrelvir/Ritonavir (Antiviral (Protease Inhibitor Combination)).
Nirmatrelvir/Ritonavir has 23 major-labeled pairs vs Ivabradine's 4.
4 major · 2 moderate · 4 minor · 10 total
- Other major peers for Ivabradine
- Darunavir
- Itraconazole
- Voriconazole
23 major · 30 moderate · 33 minor · 86 total
- Other major peers for Nirmatrelvir/Ritonavir
- Simvastatin
- Lovastatin
- Sildenafil
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.