Ivabradine and Darunavir Interaction
Drug interaction information between Ivabradine and Darunavir.
Ivabradine and Darunavir have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Ivabradine and Darunavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir prevents your body from clearing ivabradine, which causes the drug to build up to unsafe levels. This increase can lead to severe or life-threatening reactions.
FDA Label Information
Cardiac Disorders : ranolazine, ivabradine ↑ ranolazine ↑ ivabradine Co-administration is contraindicated due to potential for serious and/or life-threatening reactions.
Ivabradine Also Interacts With
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Voriconazole major
- Digoxin moderate
- Diltiazem moderate
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Ivabradine + Darunavir?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Ivabradine's 10. In the major band specifically: Ivabradine has 4 (also Itraconazole, Nirmatrelvir/Ritonavir, Voriconazole); Darunavir has 15 (also Lovastatin, Sildenafil, Lurasidone, Pimozide).
What mechanism field is on file for Ivabradine and Darunavir?
Darunavir prevents your body from clearing ivabradine, which causes the drug to build up to unsafe levels. This increase can lead to severe or life-threatening reactions.
Darunavir carries more major-labeled pairs than Ivabradine
SPL source-record counts only. This page's band is major · classes on file: Ivabradine (HCN Channel Blocker); Darunavir (HIV Protease Inhibitor).
Darunavir has 15 major-labeled pairs vs Ivabradine's 4.
4 major · 2 moderate · 4 minor · 10 total
- Other major peers for Ivabradine
- Itraconazole
- Nirmatrelvir/Ritonavir
- Voriconazole
15 major · 16 moderate · 70 minor · 101 total
- Other major peers for Darunavir
- Lovastatin
- Sildenafil
- Lurasidone
- Pimozide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.