Ivabradine and Diltiazem Interaction
Drug interaction information between Ivabradine and Diltiazem.
Ivabradine and Diltiazem have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Ivabradine and Diltiazem. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Diltiazem increases the amount of ivabradine in your body, which can slow your heart rate down to a dangerous level.
FDA Label Information
Ivabradine : Concurrent use of diltiazem increases exposure to ivabradine and may exacerbate bradycardia and conduction disturbances. Avoid concomitant use of ivabradine and diltiazem.
Ivabradine Also Interacts With
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Voriconazole major
- Digoxin moderate
Diltiazem Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Theophylline major
- Rifampin moderate
Frequently Asked Questions
What SPL severity band is on file for Ivabradine + Diltiazem?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Diltiazem has 46 labeled pairs on file vs Ivabradine's 10. In the moderate band specifically: Ivabradine has 2 (also Digoxin); Diltiazem has 7 (also Rifampin, Digoxin, Aprepitant, Metoprolol).
What mechanism field is on file for Ivabradine and Diltiazem?
Diltiazem increases the amount of ivabradine in your body, which can slow your heart rate down to a dangerous level.
Diltiazem's labeled portfolio outnumbers Ivabradine
SPL source-record counts only. This page's band is moderate · classes on file: Ivabradine (HCN Channel Blocker); Diltiazem (Calcium Channel Blocker).
4 major · 7 moderate · 35 minor · 46 total
- Other moderate peers for Diltiazem
- Rifampin
- Digoxin
- Aprepitant
- Metoprolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.