Isavuconazonium and Atorvastatin Interaction
Drug interaction information between Isavuconazonium and Atorvastatin.
Isavuconazonium and Atorvastatin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Isavuconazonium and Atorvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Isavuconazonium can increase the amount of atorvastatin in your blood by slowing down how your body processes it. This can make you more likely to experience side effects from the cholesterol medicine.
FDA Label Information
Atorvastatin Use with Caution Caution should be used when atorvastatin is used with CRESEMBA due to a potential increase in atorvastatin exposure. Monitor patients for adverse reactions that are typical of atorvastatin [see Clinical Pharmacology ( 12.3 )] .
Isavuconazonium Also Interacts With
- Itraconazole major
- Bupropion moderate
- Cyclosporine moderate
- Midazolam moderate
- Digoxin moderate
Atorvastatin Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Cyclosporine moderate
- Colchicine moderate
Frequently Asked Questions
What SPL severity band is on file for Isavuconazonium + Atorvastatin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Atorvastatin has 36 labeled pairs on file vs Isavuconazonium's 9. In the moderate band specifically: Isavuconazonium has 5 (also Bupropion, Cyclosporine, Midazolam, Digoxin); Atorvastatin has 8 (also Cyclosporine, Colchicine, Gemfibrozil, Niacin).
What mechanism field is on file for Isavuconazonium and Atorvastatin?
Isavuconazonium can increase the amount of atorvastatin in your blood by slowing down how your body processes it. This can make you more likely to experience side effects from the cholesterol medicine.
Atorvastatin carries more major-labeled pairs than Isavuconazonium
SPL source-record counts only. This page's band is moderate · classes on file: Isavuconazonium (Azole Antifungal); Atorvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Atorvastatin has 3 major-labeled pairs vs Isavuconazonium's 1. This page itself is in the moderate band, not the major band.
1 major · 5 moderate · 3 minor · 9 total
- Other moderate peers for Isavuconazonium
- Bupropion
- Cyclosporine
- Midazolam
- Digoxin
3 major · 8 moderate · 25 minor · 36 total
- Other moderate peers for Atorvastatin
- Cyclosporine
- Colchicine
- Gemfibrozil
- Niacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.