What the FDA labels say about taking them together
Atorvastatin and isavuconazonium
Isavuconazonium's FDA label of April 25, 2025 names atorvastatin in its drug interactions section; atorvastatin's label does not name isavuconazonium itself but warns about its class (Azole antifungals). The isavuconazonium label: “Atorvastatin Use with Caution Caution should be used when atorvastatin is used with CRESEMBA due to a potential increase in atorvastatin exposure.”
Check it at the source: the atorvastatin FDA label on DailyMed (effective April 15, 2024, Viatris Specialty LLC); the isavuconazonium FDA label on DailyMed (effective April 25, 2025, Astellas Pharma US, Inc.).
What does the atorvastatin label say about isavuconazonium?
Atorvastatin's label does not name isavuconazonium itself; it warns about its class (Azole antifungals):
Atorvastatin label, drug interactionsAtorvastatin plasma levels were significantly increased with concomitant administration of LIPITOR with select azole antifungals or macrolide antibiotics, due to inhibition of CYP3A4 and/or transporters [see Clinical Pharmacology (12.3) ].
Atorvastatin label, drug interactionsConsider the risk/benefit of concomitant use of other azole antifungals or macrolide antibiotics with LIPITOR.
Source: FDA drug label (Lipitor), NDA020702 (Upjohn), as published by Viatris Specialty LLC, effective April 15, 2024 (SPL set a60cc18b-0631-4cf0-b021-9f52224ece65), via openFDA; the full label on DailyMed
What does the isavuconazonium label say about atorvastatin?
Isavuconazonium label, drug interactionsAtorvastatin Use with Caution Caution should be used when atorvastatin is used with CRESEMBA due to a potential increase in atorvastatin exposure.
Source: FDA drug label (CRESEMBA), Astellas Pharma US, Inc., effective April 25, 2025 (SPL set 8f7f73b8-586a-4df0-935f-fecd4696c16c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Atorvastatin | Isavuconazonium | |
|---|---|---|
| Labeled for | High cholesterol, Angina, High triglycerides, Heart attack and coronary artery disease | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0228 per tablet 10 mg tablet | $114.00 per capsule 186 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once