Isavuconazonium and Cyclosporine Interaction
Drug interaction information between Isavuconazonium and Cyclosporine.
Isavuconazonium and Cyclosporine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Isavuconazonium and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Isavuconazonium causes cyclosporine to build up in your body by slowing its removal. This can lead to higher levels of the drug, which may cause harm.
FDA Label Information
Cyclosporine Use with Caution Concomitant administration of CRESEMBA and cyclosporine results in increase in cyclosporine exposure. Monitor drug concentrations of cyclosporine and adjust dose as needed [see Clinical Pharmacology ( 12.3 )] . ( 7 ) • Appropriate therapeutic drug monitoring and dose adjustment of immunosuppressants (i.e., tacrolimus, sirolimus, and cyclosporine) may be necessary when coadministered with CRESEMBA.
Isavuconazonium Also Interacts With
- Itraconazole major
- Atorvastatin moderate
- Bupropion moderate
- Midazolam moderate
- Digoxin moderate
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Isavuconazonium + Cyclosporine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Isavuconazonium's 9. In the moderate band specifically: Isavuconazonium has 5 (also Atorvastatin, Bupropion, Midazolam, Digoxin); Cyclosporine has 24 (also Aliskiren, Allopurinol, Amiloride, Amlodipine/Valsartan).
What mechanism field is on file for Isavuconazonium and Cyclosporine?
Isavuconazonium causes cyclosporine to build up in your body by slowing its removal. This can lead to higher levels of the drug, which may cause harm.
Cyclosporine carries more major-labeled pairs than Isavuconazonium
SPL source-record counts only. This page's band is moderate · classes on file: Isavuconazonium (Azole Antifungal); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Isavuconazonium's 1. This page itself is in the moderate band, not the major band.
1 major · 5 moderate · 3 minor · 9 total
- Other moderate peers for Isavuconazonium
- Atorvastatin
- Bupropion
- Midazolam
- Digoxin
5 major · 24 moderate · 60 minor · 89 total
- Other moderate peers for Cyclosporine
- Aliskiren
- Allopurinol
- Amiloride
- Amlodipine/Valsartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.