Isavuconazonium and Digoxin Interaction
Drug interaction information between Isavuconazonium and Digoxin.
Isavuconazonium and Digoxin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Isavuconazonium and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Isavuconazonium blocks a specific protein that helps remove digoxin from your body, which causes digoxin levels to rise.
FDA Label Information
Digoxin Use with Caution Concomitant administration of CRESEMBA and digoxin results in increase in digoxin exposure. Serum digoxin concentrations should be monitored and used for titration when dosed concurrently with CRESEMBA [see Clinical Pharmacology ( 12.3 )] . ( 7 ) • Drugs with a narrow therapeutic window that are P-gp substrates, such as digoxin, may require dose adjustment when administered concomitantly with CRESEMBA.
Isavuconazonium Also Interacts With
- Itraconazole major
- Atorvastatin moderate
- Bupropion moderate
- Cyclosporine moderate
- Midazolam moderate
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Isavuconazonium + Digoxin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Isavuconazonium's 9. In the moderate band specifically: Isavuconazonium has 5 (also Atorvastatin, Bupropion, Cyclosporine, Midazolam); Digoxin has 13 (also Sotalol, Dofetilide, Ivabradine, Dopamine).
What mechanism field is on file for Isavuconazonium and Digoxin?
Isavuconazonium blocks a specific protein that helps remove digoxin from your body, which causes digoxin levels to rise.
Digoxin carries more major-labeled pairs than Isavuconazonium
SPL source-record counts only. This page's band is moderate · classes on file: Isavuconazonium (Azole Antifungal); Digoxin (Cardiac Glycoside).
Digoxin has 2 major-labeled pairs vs Isavuconazonium's 1. This page itself is in the moderate band, not the major band.
1 major · 5 moderate · 3 minor · 9 total
- Other moderate peers for Isavuconazonium
- Atorvastatin
- Bupropion
- Cyclosporine
- Midazolam
2 major · 13 moderate · 105 minor · 120 total
- Other moderate peers for Digoxin
- Sotalol
- Dofetilide
- Ivabradine
- Dopamine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.