What the FDA labels say about taking them together
Digoxin and isavuconazonium
Isavuconazonium's FDA label of April 25, 2025 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name isavuconazonium. The isavuconazonium label: “Digoxin Use with Caution Concomitant administration of CRESEMBA and digoxin results in increase in digoxin exposure.”
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the isavuconazonium FDA label on DailyMed (effective April 25, 2025, Astellas Pharma US, Inc.).
What does the digoxin label say about isavuconazonium?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name isavuconazonium in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the isavuconazonium label say about digoxin?
Isavuconazonium label, drug interactionsDigoxin Use with Caution Concomitant administration of CRESEMBA and digoxin results in increase in digoxin exposure.
Source: FDA drug label (CRESEMBA), Astellas Pharma US, Inc., effective April 25, 2025 (SPL set 8f7f73b8-586a-4df0-935f-fecd4696c16c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Isavuconazonium | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | $114.00 per capsule 186 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once