isavuconazonium vs itraconazole
Side-by-side comparison of isavuconazonium and itraconazole Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
Antihelminthics, Antifungals and Antiprotozoals Isavuconazonium Contraindicated during and 2 weeks after itraconazole treatment.
Recommendation: Do not take these medicines together, and wait two weeks after stopping itraconazole before starting the new drug.
Cresemba
Sporanox
Cresemba is an antifungal medicine. It is used to treat serious fungal infections in adults and children.
Itraconazole capsules are an antifungal medicine. They treat fungal infections in your body.
Cresemba treats invasive aspergillosis and invasive mucormycosis. These are serious infections caused by different types of fungi. Cresemba is available as an injection for those 1 year and older. Cresemba capsules are for those 6 years and older who weigh at least 35 pounds.
Itraconazole treats fungal infections like blastomycosis, histoplasmosis, and aspergillosis. It can help both people with healthy immune systems and those with weakened immune systems. It also treats onychomycosis, a fungal infection of the toenails or fingernails.
Cresemba belongs to a class of drugs called azole antifungals. It works by stopping the growth of the fungi. This helps your body fight off the infection.
Itraconazole stops fungi from growing. It does this by interfering with the production of a substance fungi need to build their cell membranes. This eventually kills the fungus and clears the infection.
- • Nausea
- • Vomiting
- • Diarrhea
- • Headache
- • Changes in liver tests
- • Nausea
- • Rash
- • Headache
- Using the medicine for a condition it is not approved for 926
- Death 310
- Feeling sick to your stomach 143
- Fever with low white blood cell count 135
- Medicine not working 125
- Interaction with another medicine 1,118
- Medicine not working 1,100
- Using the medicine for something it's not approved for 606
- Fever 570
- Difficulty breathing 472
Cresemba can cause serious liver problems. Your doctor will check your liver function before and during treatment. Cresemba can also cause allergic reactions. Tell your doctor right away if you have any signs of a reaction, like trouble breathing or skin rash. Cresemba can harm an unborn baby. Use birth control while taking this medicine.
Itraconazole can cause congestive heart failure. You should not take this medicine if you have heart problems. Itraconazole can also interact with many other medicines. Some of these interactions can be dangerous or even fatal. Check with your doctor about all the medicines you take.
Cresemba can harm your unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Do not breastfeed while taking Cresemba.
You should not take itraconazole if you are pregnant or plan to become pregnant. It can harm your unborn baby. Talk to your doctor about safe alternatives.
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How to Read This isavuconazonium vs itraconazole Comparison
isavuconazonium is classified in the Azole Antifungal drug class, while itraconazole sits within the Azole Antifungal class. Because both drugs share the same classification, they are often considered interchangeable in theory — but clinical outcomes rarely track that cleanly. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, isavuconazonium has 1,639 submissions while itraconazole has 3,866. Those figures reflect cumulative reporting volume — not per-patient risk — so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to itraconazole blocks the body's ability to break down isavuconazonium, which can cause the drug to reach unsafe levels.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between isavuconazonium and itraconazole — always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.